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Effekte des Interleukin-6 im Rahmen des Systemic Inflammatory Response Syndrome (SIRS) beim Polytrauma an einem Interleukin-6-knock out-Modell [sic] der Maus

von Luer Christian Geerken

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[1.] Lcg/Fragment 088 05 - Diskussion
Zuletzt bearbeitet: 2015-11-17 22:35:55 Hindemith
Fragment, Gesichtet, Lcg, Mallig 2006, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 88, Zeilen: 5-23
Quelle: Mallig 2006
Seite(n): 139, Zeilen: 5ff
Multiple trauma is the most common cause of death of young adults in developed countries. Survivors often suffer from disabilities as well as social and vocational rehabilitation problems. In context of multiple trauma, traumatic brain injury (TBI) is one of the most frequent injuries. The mutual influence of TBI and extracranial trauma leads to a complex clinical picture with mechanisms that are still inadequately investigated.

With the help of an experimental multiple trauma model, which simulates typical injuries of brain-injured multiple trauma patients and describes the associated pathophysiological and immunopathological alterations, the present study aimed to show the effects of interleukin-6 on systemic inflammatory response syndrome and consecutive organ damage.

With this objective, TBI was induced in B6;129S2-IL6tmlKopf mice (IL-6 knockout = IL-6-/-) and in C57BL/6J mice (wild type = WT) and combined with blunt soft tissue and bone injury, performed by a closed femoral fracture with concomitant volumecontrolled hemorrhagic shock.

During an experimental period of 96 hours, the effects of multiple trauma and the alterations of single injury (isolated TBI and femoral fracture with hemorrhagic shock respectively) were tested by means of clinical, histological and immunological procedures and were compared between IL-6-/- and WT mice.

Multiple trauma is the most common cause of death of young adults in developed countries. Survivors often suffer from disabilities as well as social and vocational rehabilitation problems. Therefore, multiple trauma has medical relevance and also significant socio-economic importance. In the context of multiple trauma, traumatic brain injury (TBI) is one of the most frequent injuries. It has an extensive impact on the course of disease and leads to a considerable prolongation of the intensive care time and the whole rehabilitation process in addition to an increased lethality. The mutual influence of TBI and extracranial trauma leads to a complex clinical picture with mechanisms that are still inadequately investigated.

The present study aimed to develop an experimental multiple trauma model, which simulates the clinical situation of brain-injured multiple trauma patients and describes the associated pathophysiolgical and immunopathological alterations, in order to provide a basis for further research in this field. With this objective, TBI was induced in C57BL/6 mice by means of controlled cortical impact (CCI) and combined with blunt soft-tissue and bone injury that was performed by a closed femoral fracture with concomitant volume-controlled hemorrhagic shock.

The purpose was to measure the effect of TBI on pathophysiological changes following traumatic-hemorrhagic shock as well as the influence of this extracranial injury on the histopathology of the brain after TBI. During an experimental period of 96 hours, the effects of multiple trauma were tested by means of clinical, histological and immunological procedures and compared to the alterations of single injury (isolated TBI and femoral fracture with hemorrhagic shock respectively).

Anmerkungen

Ein Verweis auf die Quelle fehlt.

Sichter
(Hindemith), Klgn


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