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Crosstalk between autoreactive T cells and alveolar type II epithelial cells in inflammation and tolerance

von Dr. Marcus Gereke

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[1.] Mag/Fragment 010 01 - Diskussion
Zuletzt bearbeitet: 2014-03-10 18:11:51 Graf Isolan
BauernOpfer, Fragment, Gesichtet, Knight and Holgate 2003, Mag, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 10, Zeilen: 1-12
Quelle: Knight and Holgate 2003
Seite(n): 433, 440, 441, Zeilen: 433: r.col: 40-47; 440: r.col: 52-58 - 441: l.col: 1-4
[In addition to their role in secretion, Clara cells are believed to metabolize xenobiotic] compounds by the action of p450 mono-oxygenases and may also produce specific antiproteases such as secretory leukocyte protease inhibitor (De Water et al., 1986). More recent evidence suggests that these cells play important role for stem cells, serving as a progenitor for both ciliated and mucus secreting cells (Hong et al., 2001).

The major function of the respiratory epithelium was once thought to be primarily that of a physical barrier, but recent studies clearly indicate that it is metabolically very active with the capacity to modulate a variety of inflammatory processes through the agency of an array of receptor-mediated events. On activation, it has the capacity to produce a number of proinflammatory cytokines, proinflammatory or regulatory mediators including arachidonic acid products, nitric oxide, endothelin-1, transforming growth factor (TGF)-ß, tumour necrosis factor (TNF)-α, and cytokines such as interleukin (IL)-1, IL-6 and IL-8 (Knight and Holgate, 2003).


De Water R, Willems LN, Van Muijen GN, Franken C, Fransen JA, Dijkman JH, Kramps JA. Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. Am Rev Respir Dis. 1986 May; 133 (5): 882-90.

Hong KU, Reynolds SD, Giangreco A, Hurley CM, Stripp BR. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am J Respir Cell Mol Biol. 2001 Jun; 24 (6): 671-81.

Knight DA, Holgate ST. The airway epithelium: structural and functional properties in health and disease. Respirology. 2003 Dec; 8 (4): 432-46. Review.

[page 433]

In addition to their secretory role, Clara cells are believed to metabolize xenobiotic compounds by the action of p450 mono-oxygenases and may also produce specific antiproteases such as secretory leukocyte protease inhibitor.13 More recent evidence suggests that these cells play an important stem cell role, serving as a progenitor for both ciliated and mucus-secreting cells.14

[page 440]

The major function of the respiratory epithelium was once thought to be primarily that of a physical barrier, but recent studies clearly indicate that it is metabolically very active with the capacity to modulate a variety of inflammatory processes through the agency of an array of receptor-mediated events. On activation, it has the capacity to produce a number of pro-

[page 441]

inflammatory cytokines, pro-inflammatory or regulatory mediators including arachidonic acid products, nitric oxide, endothelin-1, TGF-β, TNFα, and cytokines such as IL-1, IL-6 and IL-8.


13 De Water R, Willems LN, Van Muijen GN et al. Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a goldlabeling technique using monoclonal antibodies. Am. Rev. Respir. Dis. 1986; 133: 882–90.

14 Hong KU, Reynolds SD, Giangreco A, Hurley CM, Stripp BR. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am. J. Respir. Cell Mol. Biol. 2001; 24: 671–81.

Anmerkungen

The source is given, but the reference to it does not indicate the extent of the borrowed text (which starts on the previous page), neither does it become clear that in large parts the source is cited literally.

Sichter
(Hindemith) Schumann


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