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Crosstalk between autoreactive T cells and alveolar type II epithelial cells in inflammation and tolerance

von Dr. Marcus Gereke

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[1.] Mag/Fragment 011 02 - Diskussion
Zuletzt bearbeitet: 2014-03-10 12:03:05 Graf Isolan
Chen et al 2004, Fragment, Gesichtet, Mag, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 11, Zeilen: 2-4, 8-10, 12-14, 16-24
Quelle: Chen et al 2004
Seite(n): 774, Zeilen: l.col: 1-14, r.col: 3-9
Alveoli are the gas exchange units of the lung and the alveolar epithelium adapts to this functional role by developing two highly specialized alveolar epithelial cell types, which are morphologically and functionally different.[...] AECII consist of about 15% of the distal lung cells and occupy 5% of the alveolar surface (Crapo et al., 1978; Crapo et al., 1982; Haies et al., 1981). [...] AECII synthesize and secrete lung surfactant, a protein-lipid complex and surface-active material. Lung surfactant stabilizes alveoli by reducing the surface tension. [...] AECII also maintain the alveolar epithelium by cell proliferation and differentiation, minimize alveolar fluid by transport of sodium from the apical to the basolateral side, and alter the inflammatory process by secretion of growth factors and cytokines.

In contrast to AECII, AECI contribute 7% of total lung cells and cover more than 95% of the alveolar surface. This thin epithelium allows the easy diffusion of gases and forms a barrier against the indiscriminate leakage of fluid into alveolar spaces. It also regulates the exchange of physiologically important solutes and water between circulating blood and the alveolar space.

Alveoli are the gas exchange units of the lung. The alveolar epithelium adapts to this functional role by developing two highly specialized alveolar epithelial cells, cuboidal type II (AEC II) and squamous type I (AEC I). AEC II consist of about 15% of the distal lung cells and occupy 5% of the alveolar surface. AEC II synthesize and secrete lung surfactant, a protein-lipid complex and surface-active material. Lung surfactant stabilizes alveoli by reducing the surface tension. AEC II also maintain the alveolar epithelium by cell proliferation and differentiation, minimize alveolar fluid by transport of sodium from the apical to the basolateral side, and alter the inflammatory process by the secretion of growth factors and cytokines. [...]

AEC I contribute 7% of total lung cells and cover over 95% of the alveolar surface. This thin epithelium allows the easy diffusion of gases and forms a barrier against the indiscriminate leakage of fluid into alveolar spaces. It also regulates the exchange of physiologically important solutes and water between circulating blood and the alveolar space.

Anmerkungen

The source text has been taken without any attribution and enhanced with some additional detail (not documented and shown with "[...]").

Sichter
(Hindemith) Schumann


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Letzte Bearbeitung dieser Seite: durch Benutzer:Graf Isolan, Zeitstempel: 20140310120508

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