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Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
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Untersuchte Arbeit:
Seite: 30, Zeilen: 13-29
Quelle: Shevach 2002
Seite(n): 397, Zeilen: 397: l.col: 14ff
Several different in vitro protocols have been described over the past few years that result in the generation of suppressor T cells. The activation of mouse or human CD4+ T cells in vitro in the presence of IL-10 has been shown to result in the generation of T cell clones with a cytokine profile different from that of T helper 1 (TH1) or T helper 2 (TH2) cells. Functionally, these T cell clones have inhibitory effects on antigen specific activation of naïve T cells that are mediated partially by IL-10 and TGF-β, and were termed T regulatory 1 (TR1) cells (Groux et al., 1997). A related approach for the generation of suppressor T cells in vitro involves the stimulation of naïve T cells with immature (im)DC. Surprisingly, although these cells produce IL-10, their suppressor phenotype resembles that of CD25+ T cells, as it is contact dependent, antigen non-specific and APC-independent. Immature DC are the ideal population to prime regulatory T cells as they are deficient in costimulatory molecules, and priming with antigen-imDC complexes might even be able to downregulate pre-existing antigen specific immune responses (Dhodapkar et al., 2001). Exposure to TGF-β has also been reported to facilitate the differentiation/expansion of suppressor T cell populations in vitro (Yamagiwa et al.; 2001).

Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med. 2001 Jan 15; 193 (2): 233-8.

Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997 Oct 16; 389 (6652): 737-42.

Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol. 2001 Jun 15; 166 (12): 7282-9.

Several different in vitro protocols have been described over the past few years that result in the generation of suppressor T cells (FIG. 1). The activation of human or mouse CD4+ T cells in vitro in the presence of IL-10 has been shown to result in the generation of T-cell clones with a cytokine profile that is different from that of T helper 1 (TH1) or TH2 cells.[...] Functionally, these T-cell clones have inhibitory effects on the antigen-specific activation of naive autologous T cells that are mediated partially by IL-10 and TGF-β. These new T cells were termed T regulatory 1 (TR1) cells67. [...]

A related approach for the generation of suppressor T cells in vitro involves the stimulation of naive T cells with iDCs. [...] Surprisingly, although these cells produced IL-10, their suppressor phenotype resembled that of CD25+ T cells, as it was contact-dependent, antigen non-specific and APC-independent. [...] Immature DCs are the ideal population to prime regulatory T cells as they are deficient in co-stimulatory molecules, and priming with antigen–iDC complexes might even be able to downregulate pre-existing antigen-specific immune responses70.

Exposure to TGF-β has also been reported to facilitate the differentiation/expansion of suppressor T-cell populations in vitro. [...]71


67. Groux, H. et al. A CD4+ T-cell subset inhibits antigen-specific TD-cell responses and prevents colitis. Nature 389, 737–742 (1997). The first definition of the TR1 population of regulatory T cells.

70. Dhodapkar, M. V., Steinman, R. M., Krasovsky, J., Munz, C. & Bhardwaj, N. Antigen-specific inhibition of effector T-cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193, 233–238 (2001).

71. Yamagiwa, S., Gray, J. D., Hashimoto, S. & Horwitz, D. A. A role of TGF-β in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 166, 7282–7289 (2001).

Anmerkungen

The source is not mentioned here although the text is identical up to marginal adaptations. Also the references to the literature are the same.

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(Hindemith), PlagProf:-)

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