von Dott. Mafalda Mucciolo
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| [1.] Mmu/Fragment 004 07 - Diskussion Zuletzt bearbeitet: 2016-02-06 20:32:27 Schumann | Fragment, Gesichtet, Katzaki 2009, Mmu, SMWFragment, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 4, Zeilen: 7-16 |
Quelle: Katzaki 2009 Seite(n): 15-16, Zeilen: 15:12-14 - 16:1-6 |
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| However, even high resolution karyotypes (Yunis 1976) are enable [sic] to detect many known microdeletion syndromes, which range from 3-5 Mb in size, and cannot detect smaller aberrations. In the 1990s the introduction of molecular cytogenetic techniques into the clinical laboratory setting represented a major advance in the ability to detect known syndromes and identify chromosomal rearrangements of unknown origin. Fluorescent in situ hybridization (FISH), which is the annealing of fluorescently labelled locus-specific probes to their complementary sequences in the genome, allowed for the detection of specific microdeletion syndromes (Trask 1991) (Fig.1b1-b2).
78. Trask BJ: Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. Trends Genet 1991; 7: 149-154. 88. Yunis J: High resolution of human chromosomes. Science 1976; 191: 1268-1270. |
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However, even high resolution karyotypes4 are unreliable for detecting many known microdeletion syndromes, which range from 3-5 Mb in size, and cannot detect smaller aberrations. [Page 16] In the 1990s the introduction of molecular cytogenetic techniques into the clinical laboratory setting represented a major advance in the ability to detect known syndromes and identify chromosomal rearrangements of unknown origin. Fluorescence in situ hybridization (FISH), which is the annealing of fluorescently labelled locus-specific probes to their complimentary [sic] sequences in the genome, allowed the detection of specific microdeletion syndromes (Fig. 2).5 4 Yunis J: High resolution of human chromosomes. Science 1976; 191: 1268-1270. 5 Trask BJ: Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. Trends Genet 1991; 7: 149-154. |
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| [2.] Mmu/Fragment 004 21 - Diskussion Zuletzt bearbeitet: 2014-11-19 19:59:04 Singulus | Fragment, Gesichtet, KomplettPlagiat, Mmu, Papa 2010, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 4, Zeilen: 21-25 |
Quelle: Papa 2010 Seite(n): 10, Zeilen: 4-9 |
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| Therefore this method is still predominantly used when the clinical phenotype is suggestive of a particular disorder. Several other FISH-based methods, including spectral karyotyping (SKY), multicolour FISH (m-FISH), and comparative genomic hybridization (CGH) have proven extremely useful in the identification of unknown chromosomal material. | There are currently a number of commercially available FISH probes for the most common disorders and this method is still predominantly used when the clinical phenotype is suggestive of a particular disorder. Several other FISH-based methods, including spectral karyotyping (SKY), multicolour FISH (m-FISH), and comparative genomic hybridization (CGH) have proven extremely useful in the identification of unknown chromosomal material. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Hindemith, Zeitstempel: 20141222160110