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Typus
Verschleierung
Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 4, Zeilen: 7-16
Quelle: Katzaki 2009
Seite(n): 15-16, Zeilen: 15:12-14 - 16:1-6
However, even high resolution karyotypes (Yunis 1976) are enable [sic] to detect many known microdeletion syndromes, which range from 3-5 Mb in size, and cannot detect smaller aberrations. In the 1990s the introduction of molecular cytogenetic techniques into the clinical laboratory setting represented a major advance in the ability to detect known syndromes and identify chromosomal rearrangements of unknown origin. Fluorescent in situ hybridization (FISH), which is the annealing of fluorescently labelled locus-specific probes to their complementary sequences in the genome, allowed for the detection of specific microdeletion syndromes (Trask 1991) (Fig.1b1-b2).

78. Trask BJ: Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. Trends Genet 1991; 7: 149-154.

88. Yunis J: High resolution of human chromosomes. Science 1976; 191: 1268-1270.

[Page 15]

However, even high resolution karyotypes4 are unreliable for detecting many known microdeletion syndromes, which range from 3-5 Mb in size, and cannot detect smaller aberrations.

[Page 16]

In the 1990s the introduction of molecular cytogenetic techniques into the clinical laboratory setting represented a major advance in the ability to detect known syndromes and identify chromosomal rearrangements of unknown origin. Fluorescence in situ hybridization (FISH), which is the annealing of fluorescently labelled locus-specific probes to their complimentary [sic] sequences in the genome, allowed the detection of specific microdeletion syndromes (Fig. 2).5


4 Yunis J: High resolution of human chromosomes. Science 1976; 191: 1268-1270.

5 Trask BJ: Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. Trends Genet 1991; 7: 149-154.

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(Graf Isolan), SleepyHollow02

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