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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 9, Zeilen: 1-13
Quelle: Papa 2010
Seite(n): 13-14, Zeilen: 13: 23-27 - 14: 1-6.9-10
Several different platforms are available for oligonucleotide arrays that range from 25- to 85mers in length, some of which were adapted from genome-wide SNP-based oligonucleotide markers and others that were created from a library of virtual probes that span the genome, and consequently can be constructed to have extremely high resolution (Shaikh 2007). Both BAC and oligonucleotide arrays have been used successfully to detect copy number changes in patients with intellectual deficit (ID), multiple congenital anomalies (MCA) and autism. A number of different array design approaches have been taken for diagnostic purposes. A targeted array is one that contains specific regions of the genome, such as the sub-telomeres and those responsible for known microdeletion/microduplication syndromes, but does not have probes that span the whole genome (Bejjani 2005, Bejjani 2006, Shaffer 2006). A whole genome or tiling path array offers full genome coverage with different resolution.

8. Bejjani, B.A. & L.G. Shaffer. 2006. Application of array-based comparative genomic hybridization to clinical diagnostics. J. Mol. Diagn. 8: 528–533.

9. Bejjani, B.A. et al. 2005. Use of targeted array-based CGH for the clinical diagnosis of chromosomal imbalance: Is less more? Am. J. Med. Genet. A 134: 259–267.

70. Shaffer L.G. et al. 2006. Targeted genomic microarray analysis for identification of chromosome abnormalities in 1500 consecutive clinical cases. J. Pediatr.149: 98–102.

72. Shaikh, T.H. 2007. Oligonucleotide arrays for highresolution analysis of copy number alteration in mental retardation/multiple congenital anomalies. Genet. Med. 9: 617–625.

[Page 13]

Several different platforms are available for oligonucleotide arrays, some of which were adapted from genome wide SNP-based oligonucleotide markers and others that were created from a library of virtual probes that span the genome, and consequently can be constructed to have extremely high resolution. [10] Both BAC and

[Page 14]

oligonucleotide arrays have been used successfully to detect copy number changes in patients with ID/MCA and autism. A number of different array design approaches have been taken for diagnostic purposes. A targeted array is one that contains specific regions of the genome, such as the subtelomeres and those responsible for known microdeletion/microduplication syndromes, but does not have probes that span the whole genome. [11] [12] [13] [...] A whole genome or tiling path array offers full genome coverage with a resolution that is dependent on the spacing of the probes.


10. Shaikh, T.H., Oligonucleotide arrays for high-resolution analysis of copy number alteration in mental retardation/multiple congenital anomalies. Genet Med, 2007. 9(9): p. 617-25.

11. Bejjani, B.A., et al., Use of targeted array-based CGH for the clinical diagnosis of chromosomal imbalance: is less more? Am J Med Genet A, 2005. 134(3): p. 259-67.

12. Bejjani, B.A. and L.G. Shaffer, Application of array-based comparative genomic hybridization to clinical diagnostics. J Mol Diagn, 2006. 8(5): p. 528-33.

13. Shaffer, L.G., Risk estimates for uniparental disomy following prenatal detection of a nonhomologous Robertsonian translocation. Prenat Diagn, 2006. 26(4): p. 303-7.

Anmerkungen

Nearly identical with nearly identical references. Nothing has been marked as a citation.

Sichter
(Graf Isolan), SleepyHollow02

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