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Seite: 16, Zeilen: 18-25
|Quelle: Walters et al 2010|
Seite(n): 672, 673, Zeilen: 672:left col. 12-17; 673:left col. 25-30
|Furthermore Walters et al; demonstrated that, in addition to the cognitive deficits or behavioural abnormalities, a 16p11.2 deletion give rise to a strongly-expressed obesity phenotype in adults, with a more variable phenotype in childhood (Walters 2011). The authors stated that the higher frequency of 16p11.2 deletions in the cohort ascertained for both phenotypes (2.9%), compared to cohorts ascertained for either phenotype alone (0.4% cognitive deficit and 0.6% obesity), confirms their impact on both obesity and developmental delay, adding to the evidence that these two phenotypes may be fundamentally interrelated.
84. Walters R. G. et al. A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2. Nature. 2010 February 4; 463(7281): 671–675
Analysis of the available clinical data for these 22 new carriers indicated that, in addition to the ascertained cognitive deficits or behavioural abnormalities (including hyperphagia, specifically identified inat least nine cases; see Supplementary Table 1), a 16p11.2 deletion gave rise to a strongly expressed obesity phenotype in adults, with a more variable phenotype in childhood.
The higher frequency of 16p11.2 deletions in the cohort ascertained for both phenotypes (2.9%), compared with cohorts ascertained for either phenotype alone (0.4% and 0.6%, respectively), confirms their impact on both obesity and developmental delay, adding to the evidence that these two phenotypes may be fundamentally interrelated.
Although the source is mentioned in the text, it is nowhere made clear that the whole passage contains of sentences which have been taken identically from various places in the original text.
Since this fragment can also be interpreted as Mmu not being able to correctly form sentences in indirect speech in English it is rated as "keine Wertung". Otherwise it would have been counted as a "pawn sacrifice". In any case, Mmu's contribution with regard to own content is negligible here.
The text preceding the passage from page 673 which is used here is presented by Mmu on page 87 of her work (see [Mmu/Fragment_087_22]).