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Kontrastverstärkte sonografische perfusionsdynamische Dignitätsuntersuchungen bei Tumoren der Glandula parotis mit immunhistochemischer Auswertung der Gefäßstruktur

von Dr. Nicole Klipphahn

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Zuletzt bearbeitet: 2017-07-31 20:14:52 WiseWoman
Fragment, Gesichtet, Klipphahn 2013, Nkl, SMWFragment, Schutzlevel sysop, Verschleierung

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WiseWoman
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Yes
Untersuchte Arbeit:
Seite: 5, Zeilen: 1 ff. (komplett)
Quelle: Klipphahn 2013
Seite(n): 49, Zeilen: 1 ff.
The dignity of the parotid gland is important for the surgical elimination of the tumor and the therapy of the patient. B-Scan sonography and the Color Doppler sonography may offer qualitative characteristics to aid in deciding which dignity a particular tumor may have.

In this study, 125 patients with tumors in the parotid gland were classified according to sonographic characteristics and compared to histology. Additionally, objective parameters of contrast agent kinetics were evaluated by a computer-assisted analysis of the time-dependent intratumaral contrast agent flow of the ultrasound contrast media SonoVue®.

92.8% of the tumors were correctly diagnosed by ultrasound in their dignity. Warthin tumors were differentiated from other types of tumors with 67% sensitivity and 86% specificity. Pleomorphic adenomas and malignant tumor had a sensitivity of less than 70%.

Sonography-based contrast agent flow kinetics such as time to peak and perfusion speed were significant for Warthin tumors. For Pleomorphic adenomas, only the sonography parameter perfusion speed was significant. When comparing benign and malignant tumors, sonography parameters were not significantly different. Histologically, the number of tumor vessels and their size did not correlate with tumor dignity or type.

Overall, neither the morphologic classification nor contrast medium analyses were able to identify the dignity of a particular parotis gland tumor sufficiently. Thus, our results did not lead to a novel and clinically useful method for diagnosing the dignity of parotid gland tumors.

The histology of parotid gland is important for the surgical elimination of the tumor. The purpose of this study was to evaluate if the B-Scan sonography and the Color Doppler sonography may offer qualitative characteristics to aid in deciding which dignity a particular tumor may have. Additional objective criteria of contrast agent kinetics were also evaluated and compared to the results of MRI.

125 patients with tumors in parotid gland were classified by sonographic characteristics and related to the MRI results. We performed a computer-assisted analysis of the time-dependent intratumaral contrast agent flow of the ultrasound contrast media SonoVue® during sonography. We compared the results to those of histological examinations. 92.8% of the tumors were correct diagnosed by ultrasound in their dignity. Warthin tumors were differentiated from other types of tumors with 67% sensitivity and 86% specificity. Pleomorphic adenomas and malignant tumor had a sensitivity of less than 70%.

Sonography-based contrast agent flow kinetics such as time to peak and perfusion speed were significant for Warthin tumors. For Pleomorphic adenomas, only the sonography parameter perfusion speed was significant. For comparisons of benign and malignant tumors, sonography parameters did not reach significance. In contrast, the MRI contrast flow kinetics parameter time to peak was significant for Warthin tumors and Pleomorphic adenomas and the parameter peak was significant for differentiating benign and malignant tumors.

Sonography contrast kinetics yielded significant parameters for benign tumors but not for malignant entities. However, these findings did not lead to novel and clinically useful results because neither the morphologic classification nor contrast medium analyses were able to identify the dignity of a particular parotis gland tumor sufficiently.

Anmerkungen

Not only is the text quite similar, but also the data reported here is the same.

Sichter
(WiseWoman), SleepyHollow02


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