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Untersuchte Arbeit:
Seite: 7, Zeilen: 1-6, 8-11
Quelle: Reschner et al 2008
Seite(n): 219, Zeilen: summary, r.col.: 9 ff.
The cross-talk between innate cells and DCs which leads to innate lymphocyte activation and DC maturation was found to be multi-directional, involving not only cell–cell contacts but also soluble factors. The final outcome of these cellular interactions may have a dramatic impact on the quality and strength of the down-stream immune responses. In addition to their role in induction of adaptive immune responses, DCs also activate natural killer (NK) cells (Fernandez et al 1999) and can produce large amounts of interferon upon encounter with viral pathogens (Kadowaki et al 2000), thus, providing a link between the adaptive and innate immune system. More recently, DC activating ability was extended to other cell types such as NK T or TCR-γδ cells (Takahashi et al 2002). Moreover, certain DC subsets share common developmental pathways with NK cells, suggesting that these cells could influence each other during differentiation (Marquez et al 1998).

Fernandez,N.C., Lozier,A., Flament,C., Ricciardi-Castagnoli,P., Bellet,D., Suter,M., Perricaudet,M., Tursz,T., Maraskovsky,E., Zitvogel,L., 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 5, 405-411.

Kadowaki,N., Antonenko,S., Lau,J.Y., Liu,Y.J., 2000. Natural interferon alpha/betaproducing cells link innate and adaptive immunity. J. Exp. Med. 192, 219-226.

Takahashi,T., Chiba,S., Nieda,M., Azuma,T., Ishihara,S., Shibata,Y., Juji,T., Hirai,H., 2002. Cutting edge: analysis of human V alpha 24+CD8+ NK T cells activated by alphagalactosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 168, 3140- 3144.

Marquez,C., Trigueros,C., Franco,J.M., Ramiro,A.R., Carrasco,Y.R., Lopez-Botet,M., Toribio,M.L., 1998. Identification of a common developmental pathway for thymic natural killer cells and dendritic cells. Blood 91, 2760-2771.

The cross-talk between innate cells and DC which leads to innate lymphocyte activation and DC maturation was found to be multi-directional, involving not only cell–cell contacts but also soluble factors. The final outcome of these cellular interactions may have a dramatic impact on the quality and strength of the down-stream immune responses, mainly in the context of early responses to tumour cells and infectious agents.

In addition to their role in induction of adaptive immune responses, DC also activate natural killer (NK) cells [13]. More recently, this DC activation was extended to other cell types such as NK T or T cell receptor (TCR)-gd cells [14,15]. Moreover, certain DC subsets share common developmental pathways with NK cells, suggesting that these cells could influence each other during differentiation [16–18].


13 Fernandez NC, Lozier A, Flament C et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999; 5:405–11.

16 Blom B, Spits H. Development of human lymphoid cells. Annu Rev Immunol 2006; 24:287–320.

17 Marquez C, Trigueros C, Franco JM et al. Identification of a common developmental pathway for thymic natural killer cells and dendritic cells. Blood 1998; 91:2760–71.

18 Perez SA, Sotiropoulou PA, Gkika DG et al. A novel myeloid-like NK cell progenitor in human umbilical cord blood. Blood 2003; 101:3444–50.

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