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Typus
BauernOpfer
Bearbeiter
SleepyHollow02, Graf Isolan
Gesichtet
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Untersuchte Arbeit:
Seite: 12, Zeilen: 1-14, 17-19
Quelle: Delcenserie et al 2008
Seite(n): 40, Zeilen: left col., 14 ff.
The immune properties of the digestive mucosa are provided by the GALT (Gut-associated lymphoid tissue). The GALT is composed of lymphoid aggregates, including the Peyer’s patches (located mainly in the small intestinal distal ileum), where induction of immune responses occurs, and mesenteric lymphoid nodes. In addition, there are large amounts of immune-competent cells in the lamina propria and the mucosal epithelium (Delcenserie et al 2008).

The intestine also protects us from pathogens because its epithelium is covered by mucus and avoids any direct contact with the microorganisms. The intestinal immune system must encounter all antigens in order to determine which ones require an immune response and which ones can be safely tolerated (Delcenserie et al 2008).

The intestinal immune system is the subject of complex regulation processes allowing the elimination of pathogenic microorganisms, while maintaining a tolerance towards food antigens and endogenous flora. Butyrate as well as other products resulting from colic fermentation, could take part in this regulation (Marteau et al 2004).

1.9. Mucosal dendritic cells

[...] It has been shown that DCs, using their dendrites, act as guard cells in the intestinal lumen without disturbing the integrity of their tight surface junctions (Niess 2008).


Delcenserie,V., Martel,D., Lamoureux,M., Amiot,J., Boutin,Y., Roy,D., 2008. Immunomodulatory effects of probiotics in the intestinal tract. Curr. Issues Mol. Biol. 10, 37-54.

Marteau,P., Seksik,P., Lepage,P., Dore,J., 2004. Cellular and physiological effects of probiotics and prebiotics. Mini. Rev. Med. Chem. 4, 889-896.

Niess,J.H., 2008. Role of mucosal dendritic cells in inflammatory bowel disease. World J. Gastroenterol. 14, 5138-5148.

The immune properties of the digestive mucosa are provided by the GALT (Gut-associated lymphoid tissue). The GALT is composed of lymphoid aggregates, including the Peyer’s patches (located mainly in the small intestinal distal ileum), where induction of immune responses occurs, and mesenteric lymphoid nodes. In addition, there are large amounts of immune-competent cells in the lamina propria and the mucosal epithelium. The intestine also protects us from pathogens because its epithelium is covered by mucus and avoids any direct contact with the micro-organisms. The intestinal immune system must encounter all antigens in order to determine which ones require an immune response and which ones can be safely tolerated.

[...] Finally, it has been shown that DCs, using their dendrites, also act as guard cells in the intestinal lumen without disturbing the integrity of their tight surface junctions. [...] The intestinal immune system is the subject of complex regulation processes allowing the elimination of pathogenic micro-organisms, while maintaining a tolerance towards food antigens and endogenous flora. Butyrate as well as other products resulting from colic fermentation, could take part in this regulation.

Anmerkungen

The source is given twice.

Sichter
(SleepyHollow02), (Graf Isolan)

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