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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
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Untersuchte Arbeit:
Seite: 13, Zeilen: 16-19, 23-26, 29-32
Quelle: Castera et al 2009
Seite(n): 1322, Zeilen: li. Sp. 16-29
Mitochondria initiate apoptosis through mitochondrial outer membrane permeabilization and the release of apoptogenic factors (e.g cytochrome c, AIF- apoptosis inducing factor) from the mitochondrial intermembrane space, leading to cell death through caspase-dependent and –independent pathways (Green and Reed 1998a; Mohamad et al 2005).

[...] Signaling cascades can also affect the inner mitochondrial membrane permeability in apoptosis and necrosis. As a consequence, cells also exhibit a loss of electrical potential across the inner membrane which is quantifiable by means of potentiometric dyes (Marchetti et al 1996).

[...] Mitochondrial dysfunction, characterized by marked reduction in mitochondrial membrane potential (Δψm), is an early step of ongoing DC death that can be triggered by many cytotoxic stimuli (McLellan et al 2000; Nencioni et al 2006b; Vassiliou et al 2004a).


Green,D.R., Reed,J.C., 1998a. Mitochondria and apoptosis. Science 281, 1309-1312.

Marchetti,P., Castedo,M., Susin,S.A., Zamzami,N., Hirsch,T., Macho,A., Haeffner,A., Hirsch,F., Geuskens,M., Kroemer,G., 1996. Mitochondrial permeability transition is a central coordinating event of apoptosis. J. Exp. Med. 184, 1155-1160.

McLellan,A.D., Terbeck,G., Mengling,T., Starling,G.C., Kiener,P.A., Gold,R., Brocker,E.B., Leverkus,M., Kampgen,E., 2000. Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development. Cell Death. Differ. 7, 933-938.

Mohamad,N., Gutierrez,A., Nunez,M., Cocca,C., Martin,G., Cricco,G., Medina,V., Rivera,E., Bergoc,R., 2005. Mitochondrial apoptotic pathways. Biocell 29, 149-161.

Nencioni,A., Garuti,A., Schwarzenberg,K., Cirmena,G., Dal Bello,G., Rocco,I., Barbieri,E. Brossart,P., Patrone,F., Ballestrero,A., 2006a. Proteasome inhibitor-induced apoptosis in human monocyte-derived dendritic cells. Eur. J. Immunol. 36, 681-689.

Vassiliou,E., Sharma,V., Jing,H., Sheibanie,F., Ganea,D., 2004a. Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells. J. Immunol. 173, 6955-6964.

Mitochondria initiate apoptosis through mitochondrial outer membrane permeabilization and the release of apoptogenic factors (e.g. cytochrome c, AIF or Smac/Diablo) from the mitochondrial intermembrane space, leading to cell death through caspase-dependent and -independent pathways. Signalling cascades can also affect the inner mitochondrial membrane permeability in apoptosis and necrosis. As a consequence, cells also exhibit a loss of electrical potential across the inner membrane which is quantifiable by means of potentiometric dyes, a measure that precedes signs of nuclear apoptosis and cell death [6]. Mitochondrial dysfunction, characterized by marked reduction in mitochondrial membrane potential (Δψm), is an early step of ongoing DC death that can be triggered by many cytotoxic stimuli [7–13].

6. Marchetti P, Castedo M, Susin SA, et al. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med. 1996; 184: 1155–60.

7. McLellan AD, Terbeck G, Mengling T, et al. Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development. Cell Death Differ. 2000; 7: 933–8.

8. Jin H, Xiao C, Zhao G, Du X, et al. Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection. J Cell Biochem. 2007; 102: 980–91.

9. Nencioni A, Garuti A, Schwarzenberg K, et al. Proteasome inhibitor-induced apoptosis in human monocyte-derived dendritic cells. Eur J Immunol. 2006; 36: 681–9.

10. Vassiliou E, Sharma V, Jing H, et al. Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells. J Immunol. 2004; 173: 6955–64.

11. Sanchez-Sanchez N, Riol-Blanco L, de la Rosa G, et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood. 2004; 104: 619–25.

12. Nicolo C, Tomassini B, Rippo MR, Testi R. UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways. Blood. 2001; 97: 1803–8.

13. Leverkus M, McLellan AD, Heldmann M, et al. MHC class II-mediated apoptosis in dendritic cells: a role for membrane-associated and mitochondrial signaling pathways. Int Immunol. 2003; 15: 993–1006. 2004; 104: 619–25.

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