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Typus
KomplettPlagiat
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Graf Isolan
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Untersuchte Arbeit:
Seite: 14, Zeilen: 1-10
Quelle: Castera et al 2009
Seite(n): 1322, Zeilen: li.Sp. 6-14, 31-34
[Compelling evidence] indicates that mitochondria-related proteins of the Bcl-2 family are crucial DC death sensors (Nencioni et al 2006a; Nicolo et al 2001; Vassiliou et al 2004b), substantiating the importance of mitochondria in DC apoptosis.

'1.10.2. Extrinsic apoptosis pathway

It is mediated by death receptors, such as the receptors for Fas and tumor necrosis factor (TNF)- related apoptosis-inducing ligand (TRAIL), and caspase-8, i.e. the major initiator caspase in this pathway. Several death receptors, including Fas, are expressed in DCs. However, DCs are known to be resistant to Fas-induced cell death through the constitutive expression of FLICE–like inhibitory protein (FLIP), a strong inhibitor of apoptosis initiated by death receptors (Willems et al 2000)


Nencioni,A., Garuti,A., Schwarzenberg,K., Cirmena,G., Dal Bello,G., Rocco,I., Barbieri,E., Brossart,P., Patrone,F., Ballestrero,A., 2006a. Proteasome inhibitor-induced apoptosis in human monocyte-derived dendritic cells. Eur. J. Immunol. 36, 681-689.

Nicolo,C., Tomassini,B., Rippo,M.R., Testi,R., 2001. UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways. Blood 97, 1803-1808.

Willems,F., Amraoui,Z., Vanderheyde,N., Verhasselt,V., Aksoy,E., Scaffidi,C., Peter,M.E., Krammer,P.H., Goldman,M., 2000. Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. Blood 95, 3478-3482.

The extrinsic apoptosis pathway is mediated by death receptors, such as the receptors for Fas and tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), and caspase-8, i.e. the major initiator caspase in this pathway. Several death receptors, including Fas, are expressed in monocyte-derived DCs. However, DCs are known to be resistant to Fas-induced cell death through the constitutive expression of FLICE (caspase-8)-like inhibitory protein (FLIP), a strong inhibitor of apoptosis initiated by death receptors [5].

[...]

[...] Compelling evidence indicates that mitochondria-related proteins of the Bcl-2 family are crucial DC death sensors [9, 12, 14–16], substantiating the importance of mitochondria in DC apoptosis.


5. Willems F, Amraoui Z, Vanderheyde N, et al. Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. Blood. 2000; 95: 3478–82.

9. Nencioni A, Garuti A, Schwarzenberg K, et al. Proteasome inhibitor-induced apoptosis in human monocyte-derived dendritic cells. Eur J Immunol. 2006; 36: 681–9.

12. Nicolo C, Tomassini B, Rippo MR, Testi R. UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways. Blood. 2001; 97: 1803–8.

14. Kriehuber E, Bauer W, Charbonnier AS, et al. Balance between NF-{kappa}B and JNK(AP-1 activity controls dendritic cell life and death. Blood. 2005; 106: 175–83.

15. Hou WS, Van Parijs L. A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Nat Immunol. 2004; 5: 583–9.

16. Kim TW, Lee JH, He L, et al. Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. Cancer Res. 2005; 65: 309–16.

Anmerkungen

Eine Referenz für "Vassiliou et al 2004b" findet sich nicht im Literaturverzeichnis von Ntx. Kein Hinweis auf eine Übernahme.

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