|Human haematopoietic stem cells (hHSCs) are rare small mononuclear cells
that tend to be noncycling or to have long cell cycles. They divide to form more
hHSCs (self-generation or symmetric division) [...] These immature
progenitors are committing to lymphocyte progenitor formation (common lymphoid
progenitors, CLPs) or to the formation of myeloid progenitors (common myeloid
progenitors, CMPs). CMPs are large blast cells that can then form megakaryocyteerythroid
progenitors (MEPs) committed to the formation of erythroid and
megakaryocytic cell lineages. CMPs can also form more restricted granulocytemacrophage
progenitors (GMPs) that are able to generate granulocytic,
macrophage, and eosinophil progenitors. These lineage-restricted cells can
generate respective mature lineage populations. 17-20
17.Kondo M, Scherer DC, Miyamoto T, et al. Cell-fate conversion of lymphoid-committed progenitors by
instructive actions of cytokines. Nature. 2000;407:383-386.
18.Kondo M, Wagers AJ, Manz MG, et al. Biology of hematopoietic stem cells and progenitors:
implications for clinical application. Annu Rev Immunol. 2003;21:759-806.
19.K A. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is
hierarchically controlled during early hematopoiesis. . Bllod. 2003;101:383-389.
20.Shizuru JA, Negrin RS, Weissman IL. Hematopoietic stem and progenitor cells: clinical and
preclinical regeneration of the hematolymphoid system. Annu Rev Med. 2005;56:509-538.
|Hematopoietic stem cells (HSCs) are rare (1 per 105 bone-marrow cells), small mononuclear cells that tend to be noncycling or to have long cell cycles. HSCs divide to form more HSC (self-generation) or to form cells committed either to lymphocyte formation (common lymphoid progenitors, CLPs) or to the formation of myeloid cells (common myeloid progenitors, CMPs) (Figure 1). CMPs are large blast cells that can then form megakaryocyteerythroid progenitors (MEPs) committed to the formation of erythroid and megakaryocytic progeny. CMPs can also form more restricted granulocyte- macrophage progenitors (GMPs) able to generate granulocytic, macrophage, and eosinophil progenitors and, through these lineage-restricted cells, generate respective mature populations (Kondo et al., 1997; Akashi et al., 2000).
Akashi, K., Traver, D., Miyamoto, T., and Weissman, I.L. (2000). A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193–197.
Kondo, M., Weissman, I.L., and Akashi, K. (1997). Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661–672.