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Functional characterization of the ‘PBX interacting protein’ (HPIP) in normal and malignant human haematopoiesis.

von Dr. Pak

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[1.] Pak/Fragment 015 01 - Diskussion
Zuletzt bearbeitet: 2014-04-06 08:36:16 Hindemith
Fragment, Gesichtet, Iwasaki and Akashi 2007, Pak, SMWFragment, Schutzlevel sysop, Verschleierung

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Hindemith
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Untersuchte Arbeit:
Seite: 15, Zeilen: 1-4, 14-17
Quelle: Iwasaki and Akashi 2007
Seite(n): 6693, Zeilen: l.col: 4-9, 13-22
hFlt3 is expressed in leukemic blasts in most cases with acute myelogenous leukemia (AML)46,47 (Carow et al., 1996; Rosnet et al., 1996), and FLT3 is one of the most frequently mutated genes in AML.48,49 The signal from FLT3 mutations should be controlled under the regulation of normal Flt3

[FIGURE 1.2.2, see: Pak/Fragment 015 05]

expression machinery, signaling from FLT3 mutations should involve HSCs and GMPs, both of which are critical targets for leukemic transformation in mouse AML models.51-54 Thus, special considerations are required in utilizing mouse models to understand the role of FLT3 mutations in human leukemogenesis.


46.Carow CE, Levenstein M, Kaufmann SH, et al. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood. 1996;87:1089-1096.

47.Rosnet O, Buhring HJ, Marchetto S, et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia. 1996;10:238-248.

48.Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532- 1542.

49.Stirewalt DL, Meshinchi S, Kussick SJ, et al. Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia. Br J Haematol. 2004;124:481-484.

51.Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17:3029-3035.

52.So CW, Karsunky H, Passegue E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell. 2003;3:161-171.

53.Huntly BJ, Shigematsu H, Deguchi K, et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell. 2004;6:587-596.

54.Wang GG, Pasillas MP, Kamps MP. Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 Cterminus. Blood. 2005;106:254-264.

hFlt3 is expressed in leukemic blasts in most cases with acute myelogenous leukemia (AML) (Carow et al., 1996; Rosnet et al., 1996), and FLT3 is one of the most frequently mutated genes in AML (Gilliland, 2002; Stirewalt and Radich, 2003). [...] Because the signal from FLT3 mutations should be controlled under the regulation of normal Flt3 expression machinery, signaling from FLT3 mutations should involve HSCs and GMPs, both of which are critical targets for leukemic transformation in mouse AML models (see the next section) (Cozzio et al., 2003; So et al., 2003; Huntly et al., 2004; Wang et al., 2005). Thus, special considerations are required in utilizing mouse models to understand the role of FLT3 mutations in human leukemogenesis.

Carow CE, Levenstein M, Kaufmann SH, Chen J, Amin S, Rockwell P et al. (1996). Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood 87: 1089–1096.

Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. (2003). Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev 17: 3029–3035.

Gilliland DG. (2002). Molecular genetics of human leukemias: new insights into therapy. Semin Hematol 39: 6–11.

Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N et al. (2004). MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6: 587–596.

Rosnet O, Buhring HJ, Marchetto S, Rappold I, Lavagna C, Sainty D et al. (1996). Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia 10: 238–248.

So CW, Karsunky H, Passegue E, Cozzio A, Weissman IL, Cleary ML. (2003). MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 3: 161–171.

Stirewalt DL, Radich JP. (2003). The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 3: 650–665.

Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P et al. (2005). Conditional MLL-CBP targets GMP and models therapyrelated myeloproliferative disease. EMBO J 24: 368–381.

Anmerkungen

The source is not given.

Note that against the usual convention in the thesis the references "(Carow et al., 1996; Rosnet et al., 1996)" are given in the main body of text.

Sichter
(Hindemith) Schumann

[2.] Pak/Fragment 015 05 - Diskussion
Zuletzt bearbeitet: 2014-04-06 07:31:11 Hindemith
BauernOpfer, Bryder et al 2006, Fragment, Gesichtet, Pak, SMWFragment, Schutzlevel sysop

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Seite: 15, Zeilen: 5-13
Quelle: Bryder_et_al_2006
Seite(n): 339, Zeilen: figure
15a diss Pak.png

Figure 1.2.2: A model of the haematopoietic developmental hierarchy. Self-renewing HSCs reside at the top of the hierarchy, thereby giving rise to a number of multipotent progenitors. Multipotent progenitors give rise to oligo-potent progenitors including the CLP, which gives rise to mature B lymphocytes, T lymphocytes, and natural killer (NK) cells. The common myeloid progenitor (CMP) gives rise to granulocyte-macrophage progenitors, which differentiate into monocytes/macrophages and granulocytes, and megakaryocyte/erythrocyte progenitors, which differentiate into megakaryocytes/platelets and erythrocytes. The cell surface phenotype of many of these cell types is shown for the murine and human systems 50(Figure adapted from Bryder D et al., 2006).


50. Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol. 2006;169:338-346.

15a source Pak.png

Figure 1. Model of the hematopoietic developmental hierarchy. Self-renewing HSCs reside at the top of the hierarchy, giving rise to a number of multipotent progenitors. Multipotent progenitors give rise to oligo-potent progenitors including the CLP, which gives rise to mature B lymphocytes, T lymphocytes, and natural killer (NK) cells. The common myeloid progenitor (CMP) gives rise to granulocyte-macrophage progenitors, which differentiate into monocytes/macrophages and granulocytes, and megakaryocyte/erythrocyte progenitors, which differentiate into megakaryocytes/platelets and erythrocytes. Both CMPs and CLPs have been proposed to give rise to dendritic cells. The cell surface phenotype of many of these cell types is shown for the murine and human systems.

Anmerkungen

The figure is sufficiently referenced, but it is not clear to the reader that the entire figure caption is also taken verbatim from the source.

Sichter
(Hindemith) Schumann


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