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Functional characterization of the ‘PBX interacting protein’ (HPIP) in normal and malignant human haematopoiesis.

von Dr. Pak

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[1.] Pak/Fragment 016 01 - Diskussion
Zuletzt bearbeitet: 2014-04-06 08:36:14 Hindemith
Fragment, Gesichtet, Iwasaki and Akashi 2007, KomplettPlagiat, Pak, SMWFragment, Schutzlevel sysop

Typus
KomplettPlagiat
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 16, Zeilen: 1-4
Quelle: Iwasaki and Akashi 2007
Seite(n): 6694, Zeilen: r.col: 1-6
Further phenotypic and functional characterization of human hematopoietic cells should be performed by utilizing improved efficient xenotransplant models. These approaches will eventually help to identify LSCs that should be a critical cellular target in leukemia treatment.55

55.Iwasaki H, Mizuno S, Mayfield R, et al. Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J Exp Med. 2005;201:1891-1897.

Further phenotypic and functional characterization of human hematopoietic cells should be performed by utilizing improved efficient xenotransplant models. These approaches will eventually help to identify LSCs that should be a critical cellular target in leukemia treatment.
Anmerkungen

The source is not given.

The text cannot be found in the referenced publication.

Sichter
(Hindemith) Schumann

[2.] Pak/Fragment 016 06 - Diskussion
Zuletzt bearbeitet: 2014-04-06 08:34:00 Hindemith
Fragment, Gesichtet, Pak, SMWFragment, Schutzlevel sysop, Verschleierung, Wikipedia hematopoietic stem cell 2008

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Verschleierung
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Hindemith
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Untersuchte Arbeit:
Seite: 16, Zeilen: 6-18
Quelle: Wikipedia hematopoietic stem cell 2008
Seite(n): 1 (online source), Zeilen: -
Using limiting dilution strategies combined with other streamlined experimental and statistical methods for examining HSCs at the clonal level, HSCs fall into three distinct lineage-biased clusters.56-58 These are quantitatively defined by the ratio “ρ” of lymphoid to myeloid cells that the HSC generates upon differentiation (which makes ñ [sic] a peripheral predictor for the clonal association of a reconstituted haematopoietic system). Balanced HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3≤ñ≤10 [sic]), in the NOD/SCID mice. Myeloid-biased (My-bi) HSC give rise to too few lymphocytes resulting in ratios 0<ρ<3, whereas lymphoid-biased (Ly-bi) HSC generate too few myeloid cells, which results in lymphoid-to-myeloid ratios of 10<ρ<00 [sic]. All three types are normal HSCs in the sense that they have self-renewal capacity and can regenerate all haematopoietic lineages (pluripotency).

56. Muller-Sieburg [sic] CE, Cho RH, Thoman M, Adkins B, Sieburg HB. Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood. 2002;100:1302-1309.

57. Muller-Sieburg [sic] CE, Cho RH, Karlsson L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood. 2004;103:4111-4118.

58. Sieburg HB, Cho RH, Dykstra B, Uchida N, Eaves CJ, Muller-Sieburg [sic] CE. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood. 2006;107:2311-2316.

Using limiting dilution strategies combined with other streamlined experimental and statistical methods for examining HSCs at the clonal level, it was shown that HSCs fall into three distinct lineage-bias[1] [2] [3] clusters. These are quantitatively defined by the ratio ρ of lymphoid to myeloid cells that HSC generate upon differentiation (which makes ρ a peripheral predictor for the clonal association of a reconstituted hematopoietic system). Balanced HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3≤ρ≤10). Myeloid-biased (My-bi) HSC give rise to too few lymphocytes resulting in ratios 0<ρ<3, whereas lymphoid-biased (Ly-bi) HSC generate too few myeloid cells, which results in lymphoid-to-myeloid ratios of 10 < ρ < oo. All three types are normal HSC in that they have self-renewal capacity and can regenerate all hematopietic [sic] lineages (pluripotency).

1. Muller-Sieburg [sic] CE, Cho RH, Thoman M, Adkins B, Sieburg HB, Deterministc [sic] regulation of hematopoietic stem cell self-renewal and differentiation. Blood. 2002; 100; 1302-9

2. Muller-Sieburg [sic] CE, Cho RH, Karlson [sic] L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished progeny with impaired IL-7 responsiveness. Blood. 2004; 103:4111-8.

3. Sieburg HB, Cho RH, Dykstra B, [sic] Eaves, CJ, Muller-Sieburg [sic], CE. The hematopoietic stem cell [sic] compartment consists of a limited number of discrete stem cell subsets. Blood. 2006; 107:2311-6. Epub 2005 Nov 15.

Anmerkungen

The source is not given.

Note that in the thesis the copied passage has a smaller line spacing than the normal text in the thesis. However there is no indication that the passage might have been taken from anywhere else.

Sichter
(Hindemith) Singulus


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