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Typus
Verschleierung
Bearbeiter
Hindemith
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Untersuchte Arbeit:
Seite: 13, Zeilen: 17-27
Quelle: Iwasaki and Akashi 2007
Seite(n): 6692, Zeilen: l.col: 18-28, 33-41
The long-term reconstitution potential of human HSCs has been described in SCID mouse repopulating assays. In the most advanced xenotransplant models by utilizing the Rag2 and IL-2Rγ double-deficient mouse40 or the NOD/SCID IL2Rγ deficient mouse.41 The CD34+CD38- or the CD34+CD90+ fractions of human bone marrow and cord blood have been shown to reconstitute all human hematolymphoid lineage cells for a long term, indicating that these CD34+ fractions contains normal human HSCs. An injection of at least 1000 cells of the human CD34+CD38- bone marrow cells is required to obtain multi-lineage, longterm reconstitution in xenotransplant models. The percent of hCD34+CD38- or hCD34+CD90+ cells that are multipotent, long-term HSCs is still difficult to determine in a engraft model.

40. Traggiai E, Chicha L, Mazzucchelli L, et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004;304:104-107.

41. Ishikawa F, Yasukawa M, Lyons B, et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood. 2005;106:1565-1573.

The long-term reconstitution potential of human HSCs has been directly shown in SCID mouse repopulating assays. In the most advanced xenotransplant models by utilizing the Rag2 and IL-2Rγ double-deficient mouse (Traggiai et al., 2004) or the NOD–SCID IL2Rγ deficient mouse (Ishikawa et al., 2005), hCD34+hCD38- or the hCD34+hCD90+ fractions of human bone marrow and cord blood can reconstitute all human hematolymphoid lineage cells for a long term, indicating that these hCD34+ fractions contains normal human HSCs. [...] injection of at least 1000 cells of the human hCD34+hCD38- bone marrow cells is required to obtain multi-lineage, long-term reconstitution in xenotransplant models. Thus, it is unknown whether the HSC that is capable of reconstitution of all lineages at the single cell level exists in human hematopoiesis, and if so, what percent of hCD34+hCD38- or hCD34+hCD90+ cells are multipotent, longterm HSCs.

Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A et al. (2004). Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304: 104–107.

Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G et al. (2005). Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106: 1565–1573.

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(Hindemith) Schumann

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