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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 20, Zeilen: 1-13
Quelle: Hapel and Stanley 2006
Seite(n): 3, 4, Zeilen: 3:18-20; 4:1-10
[Many of the signaling pathways activated by SCF, CSF] 1 and flat-3 ligand (FL) receptors, including the Ras/Raf-mitogen activated protein kinase cascade, the janus kinase (JAK)/ signal transducers and activators of transcription (STATs) pathway, Src family members and phosphatidylinositol-3-kinase (PI3K), are shared.

All three receptors are likely to exhibit ligand induced, Cbl-mediated decreases in receptor expression. The SCF and CSF-1 receptors are encoded by the proto-oncogenes c-kit and c-fms, respectively. The oncogenes derived from these two proto-oncogenes are present in mutated forms in retroviruses that cause sarcoma in cats. The mutations in the receptor genes cause constitutive activation of the receptors in the absence of cytokines, thus contributing to unregulated cell proliferation.

1.3.4. The role of transcription factors

Nuclear transcription factors are essential for stem cell lineage commitment.

[Page 3]

The Role of Transcription Factors

Experiments using gene manipulation have shown that nuclear transcription factors are essential for stem cell lineage commitment.

[Page 4]

Many of the signalling pathways activated by SCF, CSF-1 and FL receptors, including the Ras/Raf-mitogen activated protein kinase cascade, the Janus kinase (JAK) signal transducers and activation of transcription (STAT) pathway, Src family members and phosphatidylinositol-3-kinase (PI3K), are shared.43 All three receptors are likely to exhibit ligand induced, Cbl-mediated decreases in receptor expression.44

The SCF and CSF-1 receptors are encoded by the proto-oncogenes c-kit and c-fms respectively.45 The oncogenes derived from these two proto-oncogenes are present in mutated forms in retroviruses that cause sarcoma in cats. The mutations in the receptor genes cause constitutive activation of the receptors in the absence of cytokines.45 thus contributing to unregulated cell proliferation.


43. Linnekin D. Early signalling pathways activated by c-Kit in haemopoietic cells. Int J Biochem Cel Biol 1999; 31:1053-1074.

44. Lee PS, Wang Y, Dominguez MG et al. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J 1999; 18:3616-3628.

45. Sherr CJ. Colony Stimulating Factor 1 Receptor. Blood 1990; 75:1-1.

Anmerkungen

Identical, without any part of it marked as a citation. No source given.

Sichter
(Graf Isolan) Agrippina1

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