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Quelle: Ahmed_2007 Seite(n): 6, 7, Zeilen: 6: 12 ff.; 7: 4 ff. |
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| The production of mature blood cells from HSC requires three distinct genetic programs. These include: (a) the specification of HSC, (b) their self-renewal and c) their commitment/ proliferation/ differentiation. Most of the studies leading to the knowledge of genes involved in HSC genetic programs have been carried by assaying haematopoietic cells from animals deficient for the gene of interest. More recently, expression profiling strategies have been used to determine genetic and molecular signatures of HSC.68,69 Genes involved in deciding fate of HSCs during early embryogenesis include: SCL and Rbtn2/Lmo-2, which are necessary for primitive and definitive haematopoiesis.70,71 GATA-2 and AML1 are specifically required for definitive haematopoiesis.72
68.Ivanova M, Rozemuller E, Tyufekchiev N, Michailova A, Tilanus M, Naumova E. HLA polymorphism in Bulgarians defined by high-resolution typing methods in comparison with other populations. Tissue Antigens. 2002;60:496-504. 69.Georgantas RW, 3rd, Tanadve V, Malehorn M, et al. Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells. Cancer Res. 2004;64:4434-4441. 70.Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373:432-434. 71.Warren HS, Kinnear BF, Skipsey LJ, Pembrey RG. Differential expression of CD45R0 on natural killer (NK) cells in patients with an NK lymphocytosis. Immunol Cell Biol. 1994;72:500-507. 72.Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330. |
The production of mature blood cells from HSC requires three distinct genetic programs. These include: a) the specification of HSC, b) their self-renewal and c) their commitment/proliferation/differentiation (fig 1.2).
[page 7] Most of the studies leading to the knowledge of genes involved in HSC genetic programs have been carried by assaying haematopoietic cells from animals deficient for the gene of interest. More recently, expression profiling strategies have been used to determine genetic and molecular signatures of HSC (Ivanova et al., 2002). Genes involved in specifying HSC during early embryogenesis include: SCL and Rbtn2/Lmo-2 which are necessary for primitive and definitive haematopoiesis (Shivdasani et al., 1995; Warren et al., 1994). GATA-2 and AML1 are specifically required for definitive haematopoiesis (Okuda et al., 1996). Ivanova,N.B., Dimos,J.T., Schaniel,C., Hackney,J.A., Moore,K.A., and Lemischka,I.R. (2002). A stem cell molecular signature. Science 298, 601-604. Okuda,T., van Deursen,J., Hiebert,S.W., Grosveld,G., and Downing,J.R. (1996). AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330. Shivdasani,R.A., Mayer,E.L., and Orkin,S.H. (1995). Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373, 432-434. Warren,A.J., Colledge,W.H., Carlton,M.B., Evans,M.J., Smith,A.J., and Rabbitts,T.H. (1994). The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell 78, 45-57. |
The source is not mentioned. Interestingly, the author gives different publications of Warren et al. (1994) and Ivanova et al. (2002) compared to the source. |
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