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| Untersuchte Arbeit: Seite: 24, Zeilen: 1-14 |
Quelle: Wikipedia cell signaling 2008 Seite(n): 1 (online source), Zeilen: - |
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| [One of the signal transduction] pathways that are activated is called the mitogen-activated protein kinase (MAPK) pathway.
The signal transduction component labelled as "MAPK" in the pathway was originally called "ERK," so the pathway is called the MAPK/ERK pathway. The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor MYC and, thus, alter gene transcription and, ultimately, cell cycle progression. Many cellular proteins are activated downstream of the growth factor receptors (such as EGFR) that initiate this signal transduction pathway (Fig.1.3.4b). Some signaling transduction pathways respond differently depending on the amount of signaling received by the cell. For instance, the hedgehog protein activates different genes, depending on the amount of hedgehog protein present. Complex multi-component signal transduction pathways provide opportunities for feedback, signal amplification, and interactions inside one cell between multiple signals and signaling pathways. |
For example, one of the signal transduction pathways that is activated is called the mitogen-activated protein kinase (MAPK) pathway. The signal transduction component labeled as "MAPK" in the pathway was originally called "ERK" so the pathway is called the MAPK/ERK pathway. The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor MYC and thus alter gene transcription and, ultimately, cell cycle progression. Many cellular proteins are activated downstream of the growth factor receptors (such as EGFR) that initiate this signal transduction pathway.
Some signaling transduction pathways respond differently depending on the amount of signaling received by the cell. For instance the hedgehog protein activates different genes depending on the amount of hedgehog protein present. Complex multi-component signal transduction pathways provide opportunities for feedback, signal amplification, and interactions inside one cell between multiple signals and signaling pathways. |
The source is not mentioned anywhere in the thesis. Note that the internal Wikipedia links are 1-to-1 translated into underlined words in the thesis. |
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