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Angaben zur Quelle [Bearbeiten]

Autor     A. Anzueto
Titel    Impact of exacerbations on COPD
Zeitschrift    European Respiratory journal
Ausgabe    19
Jahr    2010
Nummer    116
Seiten    113-118
ISSN    1399-3003
DOI    10.1183/09059180.00002610
URL    http://err.ersjournals.com/content/19/116/113.full.pdf

Literaturverz.   

no
Fußnoten    no
Fragmente    1


Fragmente der Quelle:
[1.] Analyse:Amm/Fragment 011 01 - Diskussion
Zuletzt bearbeitet: 2014-12-25 21:03:36 Hindemith
Amm, Anzueto 2010, Fragment, KomplettPlagiat, SMWFragment, Schutzlevel, ZuSichten

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Untersuchte Arbeit:
Seite: 11, Zeilen: 1ff (entire page)
Quelle: Anzueto 2010
Seite(n): 114, 115, Zeilen: 114: r.col: last lines, 115: l.col: 1ff
[A group of patients with COPD exacerbation showed a moderate-to-large improvement] in all four domains of the Chronic Respiratory Disease Questionnaire after 10 days of treatment (Aaron SD et al, 2002). This improvement was not observed in patients who relapsed after treatment of exacerbation.

A study by Connors JR et al (Connors AF Jr. et al, 1996) reported the quality of life outcomes in patients hospitalised with acute exacerbations of COPD. At 6 months, 54% of patients required assistance with at least one activity of daily living and 49% considered their health status to be fair or poor. No analysis was conducted on the relationship between readmissions and perceived quality of life. The recovery of HRQL parameters after an acute COPD exacerbation may be determined by several factors. Spencer et al (Spencer S et al, 2001) in exacerbated patients who did not relapse during follow-up experienced an improvement in the St George's Respiratory Questionnaire (SGRQ) of 11.8 units at 1 month and 17 units after 5 months of the onset of the exacerbation. These results indicate that the recovery of health status after an exacerbation may take longer than previously expected. In contrast, median recovery time for lung function after an exacerbation is 6 days and for symptoms is 7 days (Spencer S et al, 2001). However, this recovery may be influenced by the severity of the exacerbation. The more severe the exacerbation, the longer it takes to recover. Seemungal et al (Seemungal TA et al, 2000a) showed that only 75% of patients return to their baseline peak flow values 35 days after the episode. The SGRQ and Medical Research Council questionnaire were completed by patients at the end of the study. Exacerbations were more frequent in patients with frequent previous exacerbations with an odds ratio (OR) of 5.5. Using the median number of exacerbations, patients were classified as infrequent exacerbators (0–2) or frequent exacerbators (3–8). SGRQ total score was significantly worse in frequent exacerbators, with a mean difference of 14.8.

In multiple regression analyses, exacerbation frequency was strongly correlated with SGRQ total score and component scores. Miravitlles et al (Miravitlles M et al, 2004a) confirmed the impact of exacerbations on health status. Thus, these studies showed that patients who suffered more exacerbations had significantly worse SGRQ scores compared with infrequent exacerbators, and HRQL-related questionnaires offer complementary information to lung function and respiratory symptoms to monitor the [course of recovery of an exacerbation.]

A group of patients with COPD exacerbation showed a moderate-to-large improvement in all four domains of the Chronic Respiratory Disease Questionnaire after 10 days of treatment [18]. This improvement was not observed in patients who relapsed after treatment of exacerbation.

[page 115]

A study by CONNORS JR et al. [36] reported the quality of life outcomes in patients hospitalised with acute exacerbations of COPD. At 6 months, 54% of patients required assistance with at least one activity of daily living and 49% considered their health status to be fair or poor. No analysis was conducted on the relationship between readmissions and perceived quality of life. The recovery of HRQoL parameters after an acute COPD exacerbation may be determined by several factors. SPENCER et al. [33] in exacerbated patients who did not relapse during follow-up experienced an improvement in the St George’s Respiratory Questionnaire (SGRQ) of 11.8 units at 1 month and 17 units after 5 months of the onset of the exacerbation. These results indicate that the recovery of health status after an exacerbation may take longer than previously expected. In contrast, median recovery time for lung function after an exacerbation is 6 days and for symptoms is 7 days [33]. However, this recovery may be influenced by the severity of the exacerbation. The more severe the exacerbation, the longer it takes to recover. SEEMUNGAL et al. [37] showed that only 75% of patients return to their baseline peak flow values 35 days after the episode. The SGRQ and Medical Research Council questionnaire were completed by patients at the end of the study. Exacerbations were more frequent in patients with frequent previous exacerbations (OR 5.5, p=0.001). Using the median number of exacerbations, patients were classified as infrequent exacerbators (0–2) or frequent exacerbators (3–8). SGRQ total score was significantly worse in frequent exacerbators (mean difference 14.8; p<0.001) (fig. 1).

In multiple regression analyses, exacerbation frequency was strongly correlated with SGRQ total score and component scores. MIRAVITLLES et al. [6] confirmed the impact of exacerbations on health status. Thus, these studies showed that patients who suffered more exacerbations had significantly worse SGRQ scores compared with infrequent exacerbators, and HRQoL-related questionnaires offer complementary information to lung function and respiratory symptoms to monitor the course of recovery of an exacerbation.


6 Miravitlles M, Ferrer M, Pont A, et al. Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study. Thorax 2004; 59: 387–395.

18 Aaron SD, Vandemheen KL, Clinch JJ, et al. Measurment of shortterm changes in dyspnoea and disease-specific quality of life following an acute COPD exacerbation. Chest 2002; 121: 688–696.

33 Spencer S, Calverley PMA, Burge S, et al. Health status deterioration in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163: 122–128.

36 Connors AF Jr, Dawson NV, Thomas C, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Am J Respir Crit Care Med 1996; 154: 959–967.

37 Seemungal TA, Donaldson GC, Bhowmik A, et al. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 161: 1608–1613.

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