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Angaben zur Quelle [Bearbeiten]

Autor     Peter ten Dijke, Helen M. Arthur
Titel    Extracellular control of TGFβ signalling in vascular development and disease
Zeitschrift    Nature Reviews Molecular Cell Biology
Herausgeber    Nature Publishing Group
Ausgabe    8
Datum    November 2007
Seiten    857-869
DOI    10.1038/nrm2262
URL    http://www.nature.com/nrm/journal/v8/n11/full/nrm2262.html

Literaturverz.   

yes
Fußnoten    yes
Fragmente    1


Fragmente der Quelle:
[1.] Arc/Fragment 030 01 - Diskussion
Zuletzt bearbeitet: 2014-02-26 22:35:32 Schumann
Arc, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Ten Dijke Arthur 2007, Verschleierung

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Seite: 30, Zeilen: 1-5
Quelle: Ten Dijke Arthur 2007
Seite(n): 863, Zeilen: figure caption
In sprouting angiogenesis, endothelial cells proliferate behind the tip cell of a growing branch in response to cytokines, such as VEGF, and lumens can form by vacuole fusion. Both forms of angiogenesis require the recruitment of smooth muscle cells (SMCs) to stabilize the nascent vessels.

30a diss.png

Fig. 7 – Representation of vasculogenesis and two types of angiogenesis: intussusceptive and sprouting angiogenesis. Vasculogenesis involves the differentiation of endothelial cells (ECs) from precursor angioblast cells to form a primitive plexus of capillaries, which remodel and grow by angiogenesis. Intussusceptive angiogenesis involves the splitting and growing of vessels in situ. Vessel splitting occurs by the formation of translumen pillars (arrowheads) but the molecular mechanisms are not well understood74.


74. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674.

30a source.png

Figure 3 TGFβ signalling in vasculogenesis and angiogenesis. Vasculogenesis and two types of angiogenesis are shown: intussusceptive and sprouting angiogenesis (BOX 1). Vasculogenesis involves the differentiation of endothelial cells (ECs) from precursor angioblast cells to form a primitive plexus of capillaries, which remodel and grow by angiogenesis. Intussusceptive angiogenesis involves the splitting and growing of vessels in situ in a metabolically efficient manner, and is found, for example, in the developing yolk sac and lung. Vessel splitting occurs by the formation of translumen pillars (arrowheads) but the molecular mechanisms are not well understood. In sprouting angiogenesis, endothelial cells proliferate behind the tip cell of a growing branch in response to cytokines such as vascular endothelial growth factor (VEGF) and lumens can form by vacuole fusion. Both forms of angiogenesis require the recruitment of smooth muscle cells (SMCs) to stabilize the nascent vessels.

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The source is not mentioned here. Risau (1997) does not contain the copied material.

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