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Autor     Christopher C. DeNucci, Jason S. Mitchell, and Yoji Shimizu
Titel    Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there
Zeitschrift    Critical reviews in immunology
Ausgabe    29
Jahr    2009
Nummer    2
Seiten    87-109
DOI    10.1615/CritRevImmunol.v29.i2.10
URL    http://www.dl.begellhouse.com/journals/2ff21abf44b19838,0772bd76689c273e,53a61994408514cb.html, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744463/ (Author manuscript)

Literaturverz.   

no
Fußnoten    no
Fragmente    3


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[1.] Analyse:Asa/Fragment 029 14 - Diskussion
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The continuous recirculation of naïve T cells and their subsequent migration to tissues following activation is crucial for maintaining protective immunity against invading pathogens. The preferential targeting of effector and memory T cells to tissues is instructed during priming and mediated by cell surface expressed adhesion receptors such as integrins.

Integrins are αβ heterodimeric cell surface adhesion molecules that mediate cell-extracellular matrix (ECM) and cell-cell interactions (Pribila et al., 2004), which are essential for T cell recirculation, migration into inflammatory sites and for a specific and effective immune response against foreign pathogens (Hynes, 2002; Shimizu et al., 1999).


Hynes, R.O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.

Pribila, J.T., Quale, A.C., Mueller, K.L., and Shimizu, Y. (2004). Integrins and T cell-mediated immunity. Annu Rev Immunol 22, 157-180.

Shimizu, Y., Rose, D.M., and Ginsberg, M.H. (1999). Integrins in the immune system. Adv Immunol 72, 325-380.

[Page 1 (Author Manuscript)]

The continuous recirculation of naïve T cells and their subsequent migration to tissue following activation is crucial for maintaining protective immunity against invading pathogens. The preferential targeting of effector and memory T cells to tissue is instructed during priming and mediated by cell surface expressed adhesion receptors such as integrins.

[Page 2 (Author Manuscript)]

Integrins are widely expressed cell surface adhesion molecules that mediate cell-extracellular matrix (ECM) and cell-cell interactions.2


2. Pribila JT, Quale AC, Mueller KL, Shimizu Y. Integrins and T cell-mediated immunity. Annu Rev Immunol 2004;22:157–80. [PubMed: 15032577]

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Not marked as a citation. Identical with partially identical reference.

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[2.] Analyse:Asa/Fragment 029 25 - Diskussion
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Naïve T cells express a homogeneous array of cell surface molecules that promotes recirculation through the secondary lymphoid organs of the body, including the spleen, peripheral lymph nodes (pLN), mesenteric lymph nodes (mLN) and Peyer’s patches (PP) of the small intestine. Naïve T cells express low levels of the αLβ2 (LFA-1), α4β1 (VLA-4) and α4β7 (LPAM) integrins, which bind ICAM-1, VCAM-1, and MAdCAM-1, [respectively (Springer, 1995).]

Springer, T.A. (1995). Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 57, 827-872.

Naïve T cells express a fairly homogeneous array of cell surface molecules that promotes recirculation through the SLOs of the body, including the spleen, peripheral lymph nodes (pLN), mesenteric lymph node (mLN) and peyer’s patches (PP) of the small intestine. Naïve T cells express low levels of the αLβ2 (LFA-1), α4β1 (VLA-4) and α4β7 (LPAM) integrins, which bind ICAM-1, VCAM-1, and MAdCAM-1, respectively (Fig. 1).6

6. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995;57:827–72. [PubMed: 7778885]

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[3.] Analyse:Asa/Fragment 030 01 - Diskussion
Zuletzt bearbeitet: 2014-10-09 00:07:31 Graf Isolan
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The interaction of αLβ2 with ICAM-1 is important for T cell entry into pLN and for T cell interactions with APCs. The α4β1 ligand VCAM-1 is expressed at low levels throughout the vasculature, but becomes upregulated on a wide array of tissue during inflammation (Henninger et al., 1997). MAdCAM-1, the major ligand for α4β7 is preferentially expressed at steady state in the mLN and Peyer’s patches, where it promotes entry of naïve T cells into these sites through a high affinity interaction (Berlin et al., 1993; Erle et al., 1994; von Andrian and Mackay, 2000). Both VCAM-1 and ICAM-1 are also expressed on the vasculature of the inflamed brain. In particular, VCAM-1 is known to promotes [sic] T cell entry through its interaction with α4β1 expressed on activated T cells (Engelhardt and Ransohoff, 2005).

Berlin, C., Berg, E.L., Briskin, M.J., Andrew, D.P., Kilshaw, P.J., Holzmann, B., Weissman, I.L., Hamann, A., and Butcher, E.C. (1993). Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74, 185-195.

Engelhardt, B., and Ransohoff, R.M. (2005). The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 26, 485-495.

Erle, D.J., Briskin, M.J., Butcher, E.C., Garcia-Pardo, A., Lazarovits, A.I., and Tidswell, M. 1994). Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol 153, 517-528.

Henninger, D.D., Panes, J., Eppihimer, M., Russell, J., Gerritsen, M., Anderson, D.C., and Granger, D.N. (1997). Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol 158, 1825-1832.

von Andrian, U.H., and Mackay, C.R. (2000). T-cell function and migration. Two sides of the same coin. N Engl J Med 343, 1020-1034.

[Page 2 (Author Manuscript)]

The interaction of αLβ2 with ICAM-1 is important for T cell entry into pLN and T cell interactions with antigen-presenting cells (APCs). The α4β1 ligand VCAM-1 is expressed at low levels throughout the vasculature, but becomes upregulated on a wide array of tissue during inflammation.7 α4β7 is also reported to bind with low affinity to VCAM-1 in vitro and under some circumstances may play a role in pLN entry.8–10 MAdCAM-1, the major ligand for α4β7 is preferentially expressed at steady state in the mLN and PP, where it promotes entry of naïve T cells into these sites through a high affinity interaction.11–13

[Page 9 (Author Manuscript)]

Both VCAM-1 and ICAM-1 are expressed on the vasculature of the inflamed brain. In particular, VCAM-1 is known to promote T cell entry through its interaction with α4β1 expressed on activated T cells.125


7. Henninger DD, Panes J, Eppihimer M, Russell J, Gerritsen M, Anderson DC, Granger DN. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol 1997;158:1825–32. [PubMed: 9029122]

8. Ruegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ. Role of integrin α4β7/α4βP in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol 1992;117:179–89. [PubMed: 1372909]

9. Day ES, Osborn L, Whitty A. Effect of divalent cations on the affinity and selectivity of α4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2+ activation of integrin α4β1 confers a distinct ligand specificity. Cell Commun Adhes 2002;9:205–19. [PubMed: 12699089]

10. Berlin-Rufenach C, Otto F, Mathies M, Westermann J, Owen MJ, Hamann A, Hogg N. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J Exp Med 1999;189:1467–78. [PubMed: 10224287]

11. Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. Expression and function of the MAdCAM-1 receptor, integrin α4β7, on human leukocytes. J Immunol 1994;153:517–28. [PubMed: 7517418]

12. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74:185–95. [PubMed: 7687523]

13. von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000;343:1020–34. [PubMed: 11018170]

125. Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 2005;26:485–95. [PubMed: 16039904]

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