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Autor     Charles A. Janeway, Jr. and Ruslan Medzhitov
Titel    Innate immune recognition
Zeitschrift    Annual Review of Immunology
Ausgabe    20
Datum    April 2002
Seiten    197-216
Anmerkung    PMID: 1186 1602
DOI    10.1146/annurev.immunol.20.083001.084359
URL    http://www.annualreviews.org/doi/abs/10.1146/annurev.immunol.20.083001.084359

Literaturverz.   

no
Fußnoten    no
Fragmente    3


Fragmente der Quelle:
[1.] Analyse:Asa/Fragment 010 03 - Diskussion
Zuletzt bearbeitet: 2014-08-14 13:02:35 Graf Isolan
Asa, Fragment, Janeway 2002, SMWFragment, Schutzlevel, Verschleierung, ZuSichten

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1. Introduction:

The immune system has two major components, an innate arm and an adaptive arm. The innate immune system is a universal and ancient form of host defense against infection. Innate immune system recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved metabolites produced by pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Innate immunity covers many areas of host defense against pathogenic microbes, including the recognition of pathogen-associated molecular patterns (PAMPs) (Janeway, 1989). In contrast, the adaptive immune system involves great variability and rearrangement of receptor gene segments to generate receptors, which yield myriad of antibodies or T cell receptors (TcRs) of exquisite specificity for each of potential antigens, additionally the adaptive immune system is characterized by immunological memory. However, the adaptive immune response is also responsible for allergy, autoimmunity, and the rejection of allograft.


Janeway, C.A., Jr. (1989). Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54 Pt 1, 1-13.

[Page 197]

Abstract The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. [...]

[...]

Innate immunity covers many areas of host defense against pathogenic microbes, including the recognition of pathogen-associated molecular patterns (PAMPs) (1). [...]

[...] Because the mechanism of generating receptors in the adaptive immune system involves great variability and rearrangement of receptor gene segments, the adaptive immune system can provide specific recognition of foreign antigens, immunological memory of infection,

[Page 198]

and pathogen-specific adaptor proteins. However, the adaptive immune response is also responsible for allergy, autoimmunity, and the rejection of tissue grafts.


1. Janeway CA Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1–13

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[2.] Analyse:Asa/Fragment 010 24 - Diskussion
Zuletzt bearbeitet: 2014-08-14 13:24:41 Graf Isolan
Asa, Fragment, Janeway 2002, SMWFragment, Schutzlevel, Verschleierung, ZuSichten

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The innate immune system is made of many cell types, such as macrophages, dendritic cells (DCs), mast cells, neutrophils, eosinophils and NK cells. These cells can become activated during an inflammatory response, which is a consistent sign of infection with a pathogenic microbe. Such cells rapidly differentiate into short-lived effector cells whose main role is to get rid of the infection. However, in certain cases, the innate immune system is unable to deal with the infection, and activation of an adaptive immune response becomes necessary. In these cases, the innate immune system can instruct the adaptive immune system about the nature [of the pathogenic challenge.] [Page 199]

The innate immune system is made of many cells, such as those white blood cells that are not B lymphocytes or T lymphocytes of the adaptive immune system. [...]

[...]

Among the cells that bear innate immune or germline-encoded recognition receptors are macrophages, dendritic cells (DCs), mast cells, neutrophils, eosinophils, and the so-called NK cells. These cells can become activated during an inflammatory response, which is virtually always a sign of infection with a pathogenic microbe. Such cells rapidly differentiate into short-lived effector cells whose main role is to get rid of the infection; in this they mainly succeed without recourse to adaptive immunity. However, in certain cases, the innate immune system is unable to deal with the infection, and so activation of an adaptive immune response becomes necessary. In these cases, the innate immune system can instruct the adaptive immune system about the nature of the pathogenic challenge.

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[3.] Analyse:Asa/Fragment 011 01 - Diskussion
Zuletzt bearbeitet: 2014-08-14 17:54:09 Graf Isolan
Asa, Fragment, Janeway 2002, SMWFragment, Schutzlevel, Verschleierung, ZuSichten

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It does so through cytokines and chemokines and the expression of costimulatory molecules, such as CD80 and CD86, on the surface of specialized antigen-presenting cells (APCs), with DCs as the most important ones that alarm from infection in virtually all tissues (Banchereau and Steinman, 1998; Fearon and Locksley, 1996; Janeway, 1989).

Banchereau, J., and Steinman, R.M. (1998). Dendritic cells and the control of immunity. Nature 392, 245-252.

Fearon, D.T., and Locksley, R.M. (1996). The instructive role of innate immunity in the acquired immune response. Science 272, 50-53.

Janeway, C.A., Jr. (1989). Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54 Pt 1, 1-13.

It does so through the expression of costimulatory molecules, such as CD80 and CD86, on the surface of specialized antigen-presenting cells, the most important of which are the dendritic cells that guard against infection in virtually all tissues (1, 3, 4).

1. Janeway CA Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1–13

3. Fearon DT, Locksley RM. 1996. The instructive role of innate immunity in the acquired immune response. Science 272:50–53

4. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392:245–52

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Continues from Asa/Fragment_010_24. Not marked as a citation. Taken verbatim including the references.

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