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Angaben zur Quelle [Bearbeiten]

Autor     Gary Lynch und Peter Schubert
Titel    The Use of in Vitro Brain Slices for Multidisciplinary Studies of Synaptic Function
Zeitschrift    Annual Review of Neuroscience
Datum    März 1980
Nummer    3
Seiten    1-22
DOI    10.1146/annurev.ne.03.030180.000245
URL    http://www.annualreviews.org/doi/abs/10.1146/annurev.ne.03.030180.000245

Literaturverz.   

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Fußnoten    ja
Fragmente    1


Fragmente der Quelle:
[1.] Br/Fragment 017 05 - Diskussion
Zuletzt bearbeitet: 2016-05-21 18:09:04 Schumann
BauernOpfer, Br, Fragment, Gesichtet, Lynch und Schubert 1980, SMWFragment, Schutzlevel sysop

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Seite: 17, Zeilen: 5-11, 13-17
Quelle: Lynch und Schubert 1980
Seite(n): 1, 3, Zeilen: 1:2-11; 3:1-7
Among the spectrum of experimental strategies used by neurobiologists to promote the understanding of brain function, the in vitro systems offer a number of opportunities. In in vitro studies a large number of well-defined independent variables can be readily introduced. The dependent variables are usually more accessible to measurement and can be monitored with a variety of techniques than in the case of in vivo. The interference from peripheral factors, which are more common in in vivo is greatly reduced (Lynch, 1980).

[In our studies we are performing in vitro experiments with slices from hippocampus.] The main reason is because it contains a considerable proportion of the major fibre projections and their attendant synaptic domains can be prepared. Most of the major intrinsic and extrinsic hippocampal fibre systems are organized according to a lamellar plan in which they travel at right angles to the longitudinal axis of the structure (Anderson et al., 1971, Blackstad et al., 1970).


• Andersen P, Bliss TV, Lomo T, Olsen LI, Skrede KK (1969) Lamellar organization of hippocampal excitatory pathways. Acta Physiol Scand 76:4A-5.

• Blackstad TW, Brink K, Hem J, Jeune B (1970) Distribution of hippocampal mossy fibers in the rat. An experimental study with silver impregnation methods. J Comp Neurol.138:433-49.

• Lynch G, Schubert P (1980) The use of in vitro brain slices for multidisciplinary studies of synaptic function. Annu Rev Neurosci 3:1-22.

[Seite 1]

Among the spectrum of experimental strategies used by neurobiologists to promote the understanding of brain function, the in vitro approach has found a wide and constantly growing application. In vitro systems offer a number of opportunities not available with more conventional techniques:

1. a large number of well-defined independent variables can be readily introduced,

2. dependent variables are usually more accessible to measurement and can be monitored with a greater variety of techniques than is the case in vivo,

3. interference from peripheral factors, which often compromises in vivo experiments, is greatly reduced.

[Seite 3]

Finally, and most important, hippocampal slices that contain a considerable proportion of the major fiber projections and their attendant synaptic domains can be prepared. Most of the major intrinsic and extrinsic hippocampal fiber systems are organized according to a "lamellar" plan in which they travel at right angles to the longitudinal axis of the structure (Andersen et al 1971 b, Blackstad et al 1970).


Andersen, P., Bliss, T. V. P., Skrede, K. K. 1971 b. Lamellar organization of hippocampal excitatory pathways. Exp. Brain Res. 13:222-38

Blackstad, T. W., Brink, K., Hem, J., Jeune, B. 1970. Distribution of hippocampal mossy fibers in the rat: An experimental study with silver impregnation methods. J. Camp. Neural. 138;433-50

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