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Angaben zur Quelle [Bearbeiten]

Autor     J. Kevin Leach, Glenn Van Tuyle, Peck-Sun Lin, Rupert Schmidt-Ullrich, Ross B. Mikkelsen
Titel    Ionizing Radiation-induced, Mitochondria-dependent Generation of Reactive Oxygen/Nitrogen
Zeitschrift    Cancer Research
Ausgabe    61
Datum    15. May 2001
Seiten    3894-3901
URL    http://cancerres.aacrjournals.org/content/61/10/3894.full.pdf

Literaturverz.   

yes
Fußnoten    yes
Fragmente    1


Fragmente der Quelle:
[1.] Iam/Fragment 077 21 - Diskussion
Zuletzt bearbeitet: 2014-03-12 19:32:30 Graf Isolan
Fragment, Gesichtet, Iam, Leach et al 2001, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 77, Zeilen: 21-29
Quelle: Leach et al 2001
Seite(n): 3899, Zeilen: r.col: 13-21, 25-28
Ionizing radiation initiates an oxidative event within a mitochondrion that results in the localized release of Ca2+. Adjacent mitochondria take up the Ca2+ and, as a consequence, undergo the mitochondrial permeability transition and release Ca2+ to further propagate the signal to adjacent mitochondria. Elevated mitochondrial Ca2+ levels and/or direct current (DC) depolarization can enhance mitochondrial ROS generation (Vercesi et al. 1997). This explanation could support our data as mitochondrial damage was also observed in our model. In dividing cells, a substantial fraction of the cellular mitochondria are recruited to and concentrated near the nucleus as part of the mitochondrial replication component of cell division (Davis and Clayton 1996).

Davis AF, Clayton DA (1996) In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol 135:883-893

Vercesi AE, Kowaltowski AJ, Grijalba MT, Meinicke AR, Castilho RF (1997) The role of reactive oxygen species in mitochondrial permeability transition. Biosci Rep 17:43-52

In this model, ionizing radiation initiates an oxidative event within a mitochondrion that results in the localized release of Ca2+. Adjacent mitochondria take up the Ca2+ and, as a consequence, undergo the mitochondrial permeability transition (exemplified by ΔΨ depolarization) and release Ca2+ to further propagate the signal to adjacent mitochondria. Elevated mitochondrial Ca2+ levels and/or ΔΨ depolarization can enhance mitochondrial ROS/RNS generation (34), although this may not be the only source of elevated ROS/RNS, as discussed below.

[...] In dividing cells, a substantial fraction of the cellular mitochondria are recruited to and concentrated near the nucleus as part of the mitochondrial replication component of cell division (38).


34. Vercesi, A. E., Kowaltowski, A. J., Grijalba, M. T., Meinicke, A. R., and Castilho, R. F. The role of reactive oxygen species in mitochondrial permeability transition. Biosci. Rep., 17: 43–52, 1997.

38. Davis, A., and Clayton, D. In situ localization of mitochondrial DNA replication in intact mammalian cells. J. Cell Biol., 135: 883–893, 1996.

Anmerkungen

The source is mentioned a bit further up, but with no indication whatsoever that further down a passage is taken from it verbatim and including references to the literature.

Note: copying ΔΨ and pasting it leads naturally to "DC".

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(Hindemith) Schumann

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