Fandom

VroniPlag Wiki

Quelle:Iam/Luo et al 2005

< Quelle:Iam

31.268Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.

Angaben zur Quelle [Bearbeiten]

Autor     Jun-Li Luo, Hideaki Kamata, Michael Karin
Titel    IKK/NF-κB signaling: balancing life and death — a new approach to cancer therapy
Zeitschrift    The Journal of Clinical Investigation
Ausgabe    115
Datum    October 2005
Nummer    10
Seiten    2625-2632
DOI    10.1172/JCI26322
URL    http://www.jci.org/articles/view/26322/pdf

Literaturverz.   

yes
Fußnoten    yes
Fragmente    2


Fragmente der Quelle:
[1.] Iam/Fragment 078 01 - Diskussion
Zuletzt bearbeitet: 2014-03-12 19:32:24 Graf Isolan
BauernOpfer, Fragment, Gesichtet, Iam, Luo et al 2005, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 78, Zeilen: 1-15
Quelle: Luo et al 2005
Seite(n): 2625, Zeilen: 6-9, l.col:15-27
[One function of NF-κB is promotion of cell survival through induction of] target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-κB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells of either epithelial or hematopoietic origin use NF-κB to achieve resistance to anticancer drugs, radiation, and death cytokines (Luo et al. 2005a).

Two NF-κB activation pathways exist. The first, the classical pathway (Fig. 25), is normally triggered in response to microbial and viral infections or exposure to proinflammatory cytokines that activate the tripartite IKK complex, leading to phosphorylation- induced IκB degradation. This pathway, which mostly targets p50: RelA and p50:c-Rel dimers, depends mainly on IKKβ activity (Li et al. 1999). The second pathway, the alternative pathway, leads to selective activation of p52:RelB dimers by inducing processing of the NF-κB2/p100 precursor protein, which mostly occurs as a heterodimer with RelB in the cytoplasm. This pathway is triggered by certain members of the TNF cytokine family, through selective activation of IKKα homodimers by the upstream kinase NIK (Senftleben et al. 2001). Both pathways regulate cell survival and death (Senftleben and Karin 2002).


Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189:1839-1845

Luo JL, Kamata H, Karin M (2005a) IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest 115:2625-2632

Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M (2001) Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293:1495-1499

Senftleben U, Karin M (2002) The IKK/NF-kappa B pathway. Crit Care Med 30:S18-S26

One function of NF-κB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-κB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-κB to achieve resistance to anticancer drugs, radiation, and death cytokines. [...]

[...]

Two NF-κB activation pathways exist (Figure 1). The first, the classical pathway, is normally triggered in response to microbial and viral infections or exposure to proinflammatory cytokines that activate the tripartite IKK complex, leading to phosphorylation-induced IκB degradation. This pathway, which mostly targets p50:RelA and p50:c-Rel dimers, depends mainly on IKKβ activity (4). The other pathway, the alternative pathway, leads to selective activation of p52:RelB dimers by inducing processing of the NF-κB2/p100 precursor protein, which mostly occurs as a heterodimer with RelB in the cytoplasm. This pathway is triggered by certain members of the TNF cytokine family, through selective activation of IKKα homodimers by the upstream kinase NIK (5). Both pathways regulate cell survival and death (6); [...]


4. Li, Z.W., et al. 1999. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 189:1839–1845.

5. Senftleben, U., et al. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 293:1495–1499.

6. Senftleben, U., and Karin, M. 2002. The IKK/NF-kappa B pathway. Crit. Care Med. 30(1 Suppl.):S18–S26.

Anmerkungen

The source is given, but only for the first part and without indication that text has been copied verbatim.

Sichter
(Hindemith) Schumann

[2.] Iam/Fragment 079 01 - Diskussion
Zuletzt bearbeitet: 2014-03-11 18:52:40 Graf Isolan
Fragment, Iam, KeineWertung, Luo et al 2005, SMWFragment, Schutzlevel, ZuSichten

Typus
KeineWertung
Bearbeiter
Hindemith
Gesichtet
No.png
Untersuchte Arbeit:
Seite: 79, Zeilen: 1-1
Quelle: Luo et al 2005
Seite(n): 2626, Zeilen: figure
79a diss Iam.png

Figure 25: IKK/NF-κB signaling pathways. The classical pathway is activated by a variety of inflammatory signals, resulting in coordinate expression of multiple inflammatory and innate immune genes (adopted by Luo et al. 2005b)


Luo JL, Kamata H, Karin M (2005b) IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest 115:2625-2632

79a source Iam.png

Figure 1

IKK/NF-κB signaling pathways. The classical pathway is activated by a variety of inflammatory signals, resulting in coordinate expression of multiple inflammatory and innate immune genes.

Anmerkungen

The source is given, but also the figure caption has been taken verbatim from the source. The picture is taken via copy & paste.

Sichter
(Hindemith)

Auch bei Fandom

Zufälliges Wiki