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Quelle:Iri/Hedger und Hales 2005

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Angaben zur Quelle [Bearbeiten]

Autor     M. P. Hedger, D. B. Hales
Titel    Immunophysiology of the Male Reproductive Tract
Sammlung    Knobil and Neill's Physiology of Reproduction, Volume 1
Herausgeber    Jimmey D. Neill (Editor in chief), David M. de Kretser (Section editor)
Ort    Amsterdam (u.a.)
Verlag    Elsevier/Academic Press
Ausgabe    3rd edition
Jahr    2006
Seiten    1195-1286
ISBN    0-12-515401-1
URL    http://books.google.de/books?id=1_1cDe92k_YC&dq
Fragmente    1


Fragmente der Quelle:
[1.] Analyse:Iri/Fragment 005 01 - Diskussion
Zuletzt bearbeitet: 2014-03-21 17:43:22 Schumann
Fragment, Gesichtet, Hedger und Hales 2005, Iri, SMWFragment, Schutzlevel, Verschleierung

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Graf Isolan
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Untersuchte Arbeit:
Seite: 5, Zeilen: 1ff (komplett)
Quelle: Hedger und Hales 2005
Seite(n): 1201, Zeilen: li.Sp. 3-33
[These cells remain in] intimate contact with their adjacent Sertoli cells at all times during the spermatogenetic process, with junctional and membrane specializations providing physical contact and communication and forming the so called “blood-testis barrier” (Cheng and Mruk, 2002).

The spermatogenic cells start out as mitotically dividing precursors called spermatogonia, sitting on the basal lamina (Fig. 1.1.2). At puberty these mitotically dividing cells enter into meiosis at regular intervals, moving from the periphery of the tubule to the luminal part and becoming primary and later secondary spermatocytes. Meiosis leads to chromosomal rearrangements leading to production of haploid round spermatids (early spermatids), that subsequently undergo structural differentiation to become mature or elongated spermatids (late spermatids). Once these cells are released by the Sertoli cell into the lumen of the tubule they are called spermatozoa and the fluid secreted by the Sertoli cells sweeps the released immotile spermatozoa to the rete testes.

Tight junctions between adjacent Sertoli cells and their associated membrane specializations form an intercellular barrier, which is completely impermeable for even small molecules (Whitehead, 1999, Cheng and Mruk, 2002). This blood-testis barrier separates the spermatogonia and early meiotic cells in the basal region of the seminiferous epithelium from the adluminal spermatocytes and spermatids. In this way a large majority of the developing germ cells are [sequestered behind a physical barrier and effectively isolated from the immune system.]


Cheng, C. Y. and Mruk, D. D. (2002) Physiol Rev, 82, 825-74.

Whitehead, S. S. N. S. A. (1999) Endocrinology, An Integrated Approach, BIOS Scientific Publishers Ltd.

These cells remain in intimate contact with their adjacent Sertoli cells at all times during the spermatogenetic process, with junctional and membrane specializations providing physical contact and communication (134,135). The spermatogenic cells start out as mitotically dividing precursors called spermatogonia sitting on the basal lamina. Commencing at the time of puberty, cohorts of these mitotically dividing cells begin to enter into meiosis at regular intervals, moving from the periphery of the tubule and becoming spermatocytes in the process. Meiosis is a lengthy procedure of chromosomal rearrangements leading to production of haploid round spermatids (see Chapter 18 for details). Once these cells are released by the Sertoli cell into the tubule lumen, they are called spermatozoa, and fluid secreted by the Sertoli cells sweeps the released spermatozoa toward the rete testes.

Occluding junctions between adjacent Sertoli cells and their associated membrane specializations form an intercellular barrier that is completely impermeable even to small molecules (42,134,135). This blood-testis barrier separates the spermatogonia and early meiotic cells in the basal region of the seminiferous epithelium from the adluminal spermatocytes and spermatids. In this way, a large majority of the developing germ cells are sequestered behind a physical barrier within a highly specialized environment, and effectively isolated from the immune system (Fig. 3).


42. Dym, M., and Fawcett, D. W. (1970). The blodd-testis barrier in the rat and the physiological compartmentation of the semineferous epithelium. Biol. Reprod. 3, 308-326.

134. Cheng, C. Y., and Mruk, D. D. (2002). Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev. 82, 825-874.

135. Pelletier, R. M. (2001). The tight junctions in the testis, epididymis and vas deferens. In Tight Junctions (2nd ed. M. Cereijido and J. Anderson, Eds.), pp. 599-628. CRC Press, Boca Raton, FL.

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