Angaben zur Quelle [Bearbeiten]
| Autor | Li-Yan Zhao, Xiao-Li Zhang, Jie Shi, David H. Epstein, Lin Lu |
| Titel | Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts |
| Zeitschrift | Psychopharmacology |
| Verlag | Springer-Verlag |
| Ausgabe | 203(3) |
| Datum | April 2009 |
| Seiten | 599–608 |
| Anmerkung | The linked PDF file has a different page count as the original paper. For the purpose of the documentation, this page count has been used. |
| DOI | 10.1007/s00213-008-1406-2 |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683960/pdf/nihms-481524.pdf |
Literaturverz. |
no |
| Fußnoten | no |
| Fragmente | 1 |
| [1.] Jm/Fragment 005 01 - Diskussion Zuletzt bearbeitet: 2014-02-20 21:23:47 Schumann | Fragment, Gesichtet, Jm, SMWFragment, Schutzlevel sysop, Verschleierung, Zhao et al 2009 |
|
|
|
| Untersuchte Arbeit: Seite: 5, Zeilen: 1-19 |
Quelle: Zhao et al 2009 Seite(n): 2, 6, Zeilen: 2: 28ff; 6: 11ff |
|---|---|
| Further, the importance of stress and stress hormones during the different stages of memory processing, including reconsolidation, has been implicated in the literature (Diamond et al., 1996; Loscertales et al., 1998; Newcomer et al., 1994, 1999; Roozendaal, 2002). Stress and glucocorticoids (GCs) both enhance (Loscertales et al., 1998; Roozendaal, 2002) as well as impair (Diamond et al., 1996; Newcomer et al., 1994, 1999) memory consolidation, and memory retrieval is typically impaired (de Quervain et al., 1998; Kuhlmann et al., 2005). To date, only a few groups have studied the effects of stress or GCs on the reconsolidation of memory. Maroun and Akirav (2008) provided the first evidence that stress may exert an inhibitory effect on the reconsolidation of memory. They found that, in habituated (low arousal level) and nonhabituated (high arousal level) rats, exposure to an out-of-context stressor impaired long-term reconsolidation of object recognition memory. In a recent study conducted by Wang and colleagues (2008), morphine CPP was blocked in rats that received a cold-water stressor or corticosterone following a single-trial reactivation by disrupting reconsolidation of morphine reward memory. It was found that stress administered after drug-related memory retrieval significantly decreased subsequent recall through an impaired drug-related memory reconsolidation process, a result consistent with previous studies suggesting that stress impairs the reconsolidation of recognition memory (Maroun & Akirav 2008). However, little is known regarding the effects of stress on the reconsolidation of drug-related memories in humans. | The importance of stress and stress hormone in the different stages of memory processes including reconsolidation has been implicated in the literature (Diamond et al. 1996; Loscertales et al. 1998; Newcomer et al. 1994, 1999; Roozendaal 2002). Stress and glucocorticoids enhance (Loscertales et al. 1998; Roozendaal 2002) as well as impair (Diamond et al. 1996; Newcomer et al. 1994, 1999) memory consolidation, and memory retrieval is usually impaired (de Quervain et al. 1998; Kuhlmann et al. 2005b). Moreover, in our recent study, we found that treatment with stress or corticosterone after a single memory reactivation blocks reconsolidation of a drug-related memory in rats. However, little is known regarding the effects of stress on reconsolidation of drug-related memories in human.
[page 6] Only a few groups have studied the effects of stress or glucocorticoids on reconsolidation of memory. Maroun and Akirav (2008) provided the first evidence that stress might have an inhibitory effect on the reconsolidation of memory. They found that, in habituated (low arousal level) and nonhabituated (high arousal level) rats, exposure to an out-of-context stressor impaired long-term reconsolidation of objective recognition memory (Maroun and Akirav 2008). In our recent study, morphine CPP was blocked in rats that received a cold-water stress or corticosterone after a single-trial reactivation by disrupting reconsolidation of morphine reward memory (Wang et al. 2008). In this study, we found that stress after drug-related memory retrieval significantly decreased its subsequent recall through impaired drug-related memory reconsolidation process, a result consistent with the previous studies that stress impairs reconsolidation of recognition memory (Maroun and Akirav 2008; Wang et al. 2008). |
The source is not given. |
|