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Angaben zur Quelle [Bearbeiten]

Autor     R. G. Walters, S. Jacquemont, A. Valsesia, A. J. de Smith, D. Martinet, J. Andersson, M. Falchi, F. Chen, J. Andrieux, S. Lobbens, B. Delobel, F. Stutzmann, J. S. El-Sayed Moustafa, J.-C. Chèvre, C. Lecoeur, V. Vatin, S. Bouquillon J. L. Buxton, O. Boute, M. Holder-Espinasse, J.-M. Cuisset, M.-P. Lemaitre, A.-E. Ambresin, A. Brioschi, M. Gaillard, V. Giusti, F. Fellmann, A. Ferrarini, N. Hadjikhani, D. Campion, A. Guilmatre, A. Goldenberg, N. Calmels, J.-L. Mandel, C. Le Caignec, A. David, B. Isidor, M.-P. Cordier, S. Dupuis-Girod, A. Labalme, D. Sanlaville, M. Béri-Dexheimer, P. Jonveaux, B. Leheup, K. Õunap, E. G. Bochukova, E. Henning, J. Keogh, R. J. Ellis, K. D. MacDermot, M. M. van Haelst, C. Vincent-Delorme, G. Plessis, R. Touraine, A. Philippe, V. Malan, M. Mathieu-Dramard, J. Chiesa, B. Blaumeiser, R. F. Kooy, R. Caiazzo, M. Pigeyre, B. Balkau, R. Sladek, S. Bergmann, V. Mooser, D. Waterworth, A. Reymond, P. Vollenweider, G. Waeber, A. Kurg, P. Palta, T. Esko, A. Metspalu, M. Nelis, P. Elliott, A.-L. Hartikainen, M. I. McCarthy, L. Peltonen, L. Carlsson, P. Jacobson, L. Sjöström, N. Huang, M. E. Hurles, S. O’Rahilly, I. S. Farooqi, K. Männik, M.-R. Jarvelin, F. Pattou, D. Meyre, A. J. Walley, L. J. M. Coin, A. I. F. Blakemore, P. Froguel, and J. S. Beckmann
Titel    A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
Zeitschrift    Nature
Ausgabe    463
Datum    February 2010
Seiten    671-675
DOI    10.1038/nature08727
URL    http://www.nature.com/nature/journal/v463/n7281/full/nature08727.html

Literaturverz.   

yes
Fußnoten    yes
Fragmente    2


Fragmente der Quelle:
[1.] Mmu/Fragment 016 18 - Diskussion
Zuletzt bearbeitet: 2014-12-16 06:24:11 SleepyHollow02
Fragment, Gesichtet, KeineWertung, Mmu, SMWFragment, Schutzlevel, Walters et al 2010

Typus
KeineWertung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 16, Zeilen: 18-25
Quelle: Walters et al 2010
Seite(n): 672, 673, Zeilen: 672:left col. 12-17; 673:left col. 25-30
Furthermore Walters et al; demonstrated that, in addition to the cognitive deficits or behavioural abnormalities, a 16p11.2 deletion give rise to a strongly-expressed obesity phenotype in adults, with a more variable phenotype in childhood (Walters 2011). The authors stated that the higher frequency of 16p11.2 deletions in the cohort ascertained for both phenotypes (2.9%), compared to cohorts ascertained for either phenotype alone (0.4% cognitive deficit and 0.6% obesity), confirms their impact on both obesity and developmental delay, adding to the evidence that these two phenotypes may be fundamentally interrelated.

84. Walters R. G. et al. A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2. Nature. 2010 February 4; 463(7281): 671–675

[Page 672]

Analysis of the available clinical data for these 22 new carriers indicated that, in addition to the ascertained cognitive deficits or behavioural abnormalities (including hyperphagia, specifically identified inat least nine cases; see Supplementary Table 1), a 16p11.2 deletion gave rise to a strongly expressed obesity phenotype in adults, with a more variable phenotype in childhood.

[Page 673]

The higher frequency of 16p11.2 deletions in the cohort ascertained for both phenotypes (2.9%), compared with cohorts ascertained for either phenotype alone (0.4% and 0.6%, respectively), confirms their impact on both obesity and developmental delay, adding to the evidence that these two phenotypes may be fundamentally interrelated.

Anmerkungen

Although the source is mentioned in the text, it is nowhere made clear that the whole passage contains of sentences which have been taken identically from various places in the original text.

Since this fragment can also be interpreted as Mmu not being able to correctly form sentences in indirect speech in English it is rated as "keine Wertung". Otherwise it would have been counted as a "pawn sacrifice". In any case, Mmu's contribution with regard to own content is negligible here.

The text preceding the passage from page 673 which is used here is presented by Mmu on page 87 of her work (see [Mmu/Fragment_087_22]).

Sichter
(Graf Isolan), SleepyHollow02

[2.] Mmu/Fragment 087 22 - Diskussion
Zuletzt bearbeitet: 2016-02-06 20:31:52 Schumann
BauernOpfer, Fragment, Gesichtet, Mmu, SMWFragment, Schutzlevel sysop, Walters et al 2010

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 87, Zeilen: (21-22).22-26
Quelle: Walters et al 2010
Seite(n): 673, Zeilen: left col. 21-25
Furthermore Walters et al; demonstrated that a 16p11.2 deletion give rise to a strongly-expressed obesity phenotype. Possible explanations include a direct causal relationship between obesity and developmental delay; the involvement of the same or related regulatory pathways; or different outcomes of the same set of behavioural disorders with complex pleiotropic effects and variable ages of onset and expressivities (Walters 2010).

84. Walters R. G. et al. A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2. Nature. 2010 February 4; 463(7281): 671–675

Possible explanations include a direct causal relationship between obesity and developmental delay, the involvement of the same or related regulatory pathways, or different outcomes of the same set of behavioural disorders with complex pleiotropic effects and variable ages of onset and expressivities.
Anmerkungen

The source is mentioned at the end, but the reader cannot know that this passage has been copied verbatim.

Sichter
(Graf Isolan), SleepyHollow02

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