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Angaben zur Quelle [Bearbeiten]

Autor     A. Corthay
Titel    A Three-cell Model for Activation of Naïve T Helper Cells
Zeitschrift    Scandinavian Journal of Immunology
Verlag    John Wiley & Sons
Ausgabe    64
Datum    7. Juli 2006
Nummer    2
Seiten    93-96
DOI    10.1111/j.1365-3083.2006.01782.x
URL    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2006.01782.x/pdf

Literaturverz.   

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Fußnoten    ja
Fragmente    1


Fragmente der Quelle:
[1.] Ntx/Fragment 006 05 - Diskussion
Zuletzt bearbeitet: 2014-11-29 19:20:36 Graf Isolan
BauernOpfer, Corthay 2006, Fragment, Ntx, SMWFragment, Schutzlevel, ZuSichten

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Untersuchte Arbeit:
Seite: 6, Zeilen: 5-13
Quelle: Corthay 2006
Seite(n): 93, Zeilen: li.Sp. 2-10.14-21 - re.Sp, 1-3
DCs activate naïve Th cells by: 1) the antigen-specific recognition of peptides in the context of MHC molecules on the DC by TCR; 2) co-stimulatory molecules CD80 and CD86 which bind to CD28 on the T cell (Linsley et al 1990) and direct T-cell differentiation into various subsets such as Th1 and Th2 by secreting polarizing cytokines which bind to their receptors on the T cell (Scott 1993). A given Th-cell subset is characterized by its cytokine-secretion profile which is intimately associated to the effector functions. Th1 cells mediate cellular immunity against intracellular bacteria and viruses by secreting cytokines such as IFN-γ and tumour necrosis factor-α (TNF-α), Th2 cells regulate humoral immunity and immunity against extracellular parasites by producing IL-4, IL-5 and IL-13 (Corthay 2006).

Corthay,A., 2006. A three-cell model for activation of naive T helper cells. Scand. J. Immunol. 64, 93-96.

Linsley,P.S., Clark,E.A., Ledbetter,J.A., 1990. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. U. S. A 87, 5031-5035.

Scott,P., 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260, 496-497.

Immunology students are usually taught that the activation of naı¨ve Th cells is the result of a two-cell interaction between the Th cell and a dendritic cell (DC), and that three signals are involved (Fig. 1A). Signal one is the antigen-specific recognition of peptides in the context of major histocompatibility complex (MHC) molecules on the DC by the T-cell receptor (TCR) [1, 2]. Signal two is provided by the co-stimulatory molecules CD80 and CD86 which bind to CD28 on the T cell [3, 4]. [...] Signal three, which relies on the binding of a polarizing cytokine to its receptor on the T cell, directs T-cell differentiation into various subsets such as Th1 and Th2 [7]. A given Th-cell subset is characterized by its cytokine-secretion profile which is intimately associated to the effector functions. Th1 cells mediate cellular immunity against intracellular bacteria and viruses by secreting cytokines such as IFN-γ and tumour necrosis factor-α (TNF-α) Th2 cells regulate humoral immunity and immunity against extracellular parasites by producing IL-4, IL-5 and IL-13.

1. Burnet FM. The Clonal Selection Theory of Acquired Immunity. Nashville, TN:Vanderbilt University Press, 1959.

2. Zinkernagel RM. Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes. Nature 1974; 251:230.

3. Cunningham AJ, Lafferty KJ. A simple conservative explanation of the H-2 restriction of interactions between lymphocytes. Scand J Immunol 1977;6:1.

4. Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A 1990;87:5031.

7. Scott P. IL-12: initiation cytokine for cell-mediated immunity. Science 1993;260:496.

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