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Angaben zur Quelle [Bearbeiten]

Autor     A. Reschner, P. Hubert, P. Delvenne, J. Boniver and N. Jacobs
Titel    Innate lymphocyte and dendritic cell cross-talk: a key factor in the regulation of the immune response
Zeitschrift    Clinical and Experimental Immunology
Jahr    2008
Jahrgang    152
Seiten    219–226

Literaturverz.   

ja
Fußnoten    ja
Fragmente    3


Fragmente der Quelle:
[1.] Ntx/Fragment 001 22 - Diskussion
Zuletzt bearbeitet: 2014-11-27 20:31:09 Graf Isolan
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• Natural killer cells (NK), Natural killer T cells (NK T) and T cell receptor γδ (TCR-γδ) lymphocytes constitute particular populations of lymphocytes which play important roles in innate immunity and share similar functions upon activation, such as expansion, secretion of soluble factors (cytokines, chemokines) and cytolytic activity (Hamerman et al 2005; Lauwerys et al 2000; Vivier 2006).

Hamerman,J.A., Ogasawara,K., Lanier,L.L., 2005. NK cells in innate immunity. Curr. Opin. Immunol. 17, 29-35.

Lauwerys,B.R., Garot,N., Renauld,J.C., Houssiau,F.A., 2000. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18. J. Immunol. 165, 1847-1853.

Vivier,E., 2006. What is natural in natural killer cells? Immunol. Lett. 107, 1-7.

Natural killer, NK T and TCR-γδ lymphocytes constitute particular populations of lymphocytes which play important roles in innate immunity and share similar functions upon activation, such as expansion, secretion of soluble factors (cytokines, chemokines) and cytolytic activity [19–22].

19 Hamerman JA, Ogasawara K, Lanier LL. NK cells in innate immunity. Curr Opin Immunol 2005; 17:29–35.

20 Hayday AC. [Gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol 2000;18:975–1026.

21 Lauwerys BR, Garot N, Renauld JC, Houssiau FA. Cytokine production and killer activity of NK/T–NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18. J Immunol 2000;165:1847–53.

22 Vivier E.What is natural in natural killer cells? Immunol Lett 2006; 107:1–7.

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[2.] Ntx/Fragment 007 01 - Diskussion
Zuletzt bearbeitet: 2014-10-21 05:36:16 SleepyHollow02
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The cross-talk between innate cells and DCs which leads to innate lymphocyte activation and DC maturation was found to be multi-directional, involving not only cell–cell contacts but also soluble factors. The final outcome of these cellular interactions may have a dramatic impact on the quality and strength of the down-stream immune responses. In addition to their role in induction of adaptive immune responses, DCs also activate natural killer (NK) cells (Fernandez et al 1999) and can produce large amounts of interferon upon encounter with viral pathogens (Kadowaki et al 2000), thus, providing a link between the adaptive and innate immune system. More recently, DC activating ability was extended to other cell types such as NK T or TCR-γδ cells (Takahashi et al 2002). Moreover, certain DC subsets share common developmental pathways with NK cells, suggesting that these cells could influence each other during differentiation (Marquez et al 1998).

Fernandez,N.C., Lozier,A., Flament,C., Ricciardi-Castagnoli,P., Bellet,D., Suter,M., Perricaudet,M., Tursz,T., Maraskovsky,E., Zitvogel,L., 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 5, 405-411.

Kadowaki,N., Antonenko,S., Lau,J.Y., Liu,Y.J., 2000. Natural interferon alpha/betaproducing cells link innate and adaptive immunity. J. Exp. Med. 192, 219-226.

Takahashi,T., Chiba,S., Nieda,M., Azuma,T., Ishihara,S., Shibata,Y., Juji,T., Hirai,H., 2002. Cutting edge: analysis of human V alpha 24+CD8+ NK T cells activated by alphagalactosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 168, 3140- 3144.

Marquez,C., Trigueros,C., Franco,J.M., Ramiro,A.R., Carrasco,Y.R., Lopez-Botet,M., Toribio,M.L., 1998. Identification of a common developmental pathway for thymic natural killer cells and dendritic cells. Blood 91, 2760-2771.

The cross-talk between innate cells and DC which leads to innate lymphocyte activation and DC maturation was found to be multi-directional, involving not only cell–cell contacts but also soluble factors. The final outcome of these cellular interactions may have a dramatic impact on the quality and strength of the down-stream immune responses, mainly in the context of early responses to tumour cells and infectious agents.

In addition to their role in induction of adaptive immune responses, DC also activate natural killer (NK) cells [13]. More recently, this DC activation was extended to other cell types such as NK T or T cell receptor (TCR)-gd cells [14,15]. Moreover, certain DC subsets share common developmental pathways with NK cells, suggesting that these cells could influence each other during differentiation [16–18].


13 Fernandez NC, Lozier A, Flament C et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999; 5:405–11.

16 Blom B, Spits H. Development of human lymphoid cells. Annu Rev Immunol 2006; 24:287–320.

17 Marquez C, Trigueros C, Franco JM et al. Identification of a common developmental pathway for thymic natural killer cells and dendritic cells. Blood 1998; 91:2760–71.

18 Perez SA, Sotiropoulou PA, Gkika DG et al. A novel myeloid-like NK cell progenitor in human umbilical cord blood. Blood 2003; 101:3444–50.

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[3.] Ntx/Fragment 010 12 - Diskussion
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Table 1: Populations of DCs in mice and humans.

DC subsets Tissue distribution Species Immature phenotype Mature phenotype Bone marrow derived DC Dermis, airways, intestine, thymus, spleen, liver, lymphoid tissue Mouse CD11c+CD8α- CD11b+MHCII+ TLR-1–3+/−TLR-2,4–9+ CD83+ CCR7+ CD80++ CD86++ MHCII++ Human CD1a+ CD14- CD11c++CD11b++ CD1c+ CD209+ MHC-II+ TLR-1, 6+,3,8++ CD40+ Plasmacytoid DC Lymphoid organs, liver, lung, skin Mouse CD11c+/−B220+Ly-6C+CD11b- PDCA+ MHC-II+ TLR-2–9+ Human CD14-CD11c-CD123++ BDCA2+ ILT7+ MHC-II+ TLR-7,9++ CD8α+DC Thymus, spleen, lymph node, liver Mouse CD8α+CD4-CD11c++ CD11b CD205++-TLR-2–4,6,8,9+ Human Not identified Langerhans cells Mucosal epithelia, epidermis Mouse CD8α- CD11c+ CD205++ Ecadherin+ CD207+ E-cadherin +/− Human CD14+/−CD11c+CD1a+ Ecadherin+ CD207+CCR6+ DC, dendritic cells. +/−, low; ++, high.

Table 1. Populations of DC in mice and humans. DC subsets Tissue distribution Species Immature phenotype Mature phenotype Bone marrow derived DC Dermis, airways, intestine, thymus, spleen, liver, lymphoid tissue Mouse CD11c+CD8a- CD11b+MHC-II+ TLR-1–3+/-TLR-2,4–9+ CD83+ CCR7+ CD80++ CD86++ MHC-II++ Human CD1a+ CD14-CD11c++CD11b++ CD1c+ CD209+ MHC-II+ TLR-1, 6+,3,8++ CD40+ Plasmacytoid DC Lymphoid organs, liver, lung, skin Mouse CD11c+/-B220+Ly-6C+CD11b- PDCA+ MHC-II+ TLR-2–9+ Human CD14-CD11c-CD123+ + BDCA2+ ILT7+ MHC-II+ TLR-7,9++ CD8a+DC Thymus, spleen, lymph node, liver Mouse CD8a+CD4-CD11c++ CD11b CD205++ -TLR-2–4,6,8,9+ Human Not identified Langerhans cells Mucosal epithelia, epidermis Mouse CD8a- CD11c+ CD205++ E-cadherin+CD207+ E-cadherin +/- Human CD14+/-CD11c+CD1a+ E-cadherin+CD207+CCR6+ DC, dendritic cells. +/-, low; ++, high.
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