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Titel    Innate immune system
Herausgeber    Wikipedia
Jahr    2008
URL    http://en.wikipedia.org/w/index.php?title=Innate_immune_system&oldid=256317868

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1.1.1. Innate immune system

The innate immune system comprises white blood cells which are known as leukocytes and mechanisms that defend the host from infection by other organisms, in a non-specific manner. This means that the cells of the innate system recognize and respond to pathogens in a generic way. Innate immune system provides immediate defense against infection, and is found in all classes of plant and animal life (Rasmussen et al 2009).

The major functions of the vertebrate innate immune system include (Janeway, Jr. 2001; Kumar et al 2009; Mogensen 2009):

• Recruiting immune cells to sites of infection and inflammation, through the production of chemical factors, including specialized chemical mediators, called cytokines.

• Activation of the complement cascade to identify bacteria, activate cells and to promote clearance of dead cells or antibody complexes.

• The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialized white blood cells.

• Activation of the adaptive immune system through a process known as antigen presentation.


Janeway,C.A., Jr., 2001b. How the immune system protects the host from infection. Microbes. Infect. 3, 1167-1171.

Kumar,H., Kawai,T., Akira,S., 2009. Pathogen recognition in the innate immune response. Biochem. J. 420, 1-16.

Mogensen,T.H., 2009. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin. Microbiol. Rev. 22, 240-73, Table.

Rasmussen,S.B., Reinert,L.S., Paludan,S.R., 2009. Innate recognition of intracellular pathogens: detection and activation of the first line of defense. APMIS 117, 323-337.

Innate immune system

[...]

The innate immune system comprises the cells and mechanisms that defend the host from infection by other organisms, in a non-specific manner. This means that the cells of the innate system recognize, and respond to, pathogens in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host.[1] Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life.

Functions

[...][2]

The major functions of the vertebrate innate immune system include:

• Recruiting immune cells to sites of infection and inflammation, through the production of chemical factors, including specialized chemical mediators, called cytokines.

• Activation of the complement cascade to identify bacteria, activate cells and to promote clearance of dead cells or antibody complexes.

• The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialized white blood cells.

• Activation of the adaptive immune system through a process known as antigen presentation.


1. Alberts, Bruce; Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walters (2002). Molecular Biology of the Cell; Fourth Edition. New York and London: Garland Science. ISBN 0-8153-3218-1.

2. Janeway, Charles; Paul Travers, Mark Walport, and Mark Shlomchik (2001). Immunobiology; Fifth Edition. New York and London: Garland Science. ISBN 0-8153-4101-6. .

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