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Angaben zur Quelle [Bearbeiten]

Autor     Bruce Alberts
Titel    Essential Cell Biology (2nd edition)
Verlag    Garland Science
Jahr    2004
ISBN    0815334818, 9780815334811
URL    http://www.accessexcellence.org/RC/VL/GG/ecb/RNA_transcription.php GB

Literaturverz.   

no
Fußnoten    yes
Fragmente    1


Fragmente der Quelle:
[1.] Pak/Fragment 023 01 - Diskussion
Zuletzt bearbeitet: 2014-04-26 09:43:50 Guckar
BauernOpfer, Essential cell biology 2004, Fragment, Gesichtet, Pak, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 23, Zeilen: 1-13
Quelle: Essential cell biology 2004
Seite(n): -, Zeilen: Figure 8-10
23a diss Pak.png

Figure 1.3.4b: Above figure is a simple illustration of basal transcription regulation mediated by general transcription factors (GTFs) in a eukarayotic cell (Figure adapted from Essential cell biology E-2). To begin transcription, eukaryotic RNA polymerase II requires the general transcription factors. These transcription factors are called TFIIA, TFIIB, and so on. (A) The promoter contains a DNA sequence called the TATA box, which are located 25 nucleotides away from the site where transcription is initiated. (B) The TATA box is recognized and bound by transcription factor TFIID, which then enables the adjacent binding of TFIIB. (C) For simplicity the DNA distortion produced by the binding of TFIID is not shown. (D) The rest of the general transcription factors as well as the RNA polymerase itself assemble at the promoter. (E) TFIIH uses ATP to pry apart the double helix at the transcription start point, allowing transcription to begin. TFIIH also phosphorylates RNA polymerase II, releasing it from the general factors so it can begin the elongation phase of transcription. As shown, the site of phosphorylation is a long polypeptide tail that extends from the polymerase molecule.

23a source Pak.png

To begin transcription, eucaryotic RNA polymerase II requires the general transcription factors. These transcription factors are called TFIIA, TFIIB, and so on. (A) The promoter contains a DNA sequence called the TATA box, which is located 25 nucleotides away from the site where transcription is initiated. (B) The TATA box is recognized and bound by transcription factor TFIID, which then enables the adjacent binding of TFIIB. (C) For simplicity the DNA distortion produced by the binding of TFIID is not shown. (D) The rest of the general transcription factors as well as the RNA polymerase itself assemble at the promoter. (E) TFIIH uses ATP to pry apart the double helix at the transcription start point, allowing transcription to begin. TFIIH also phosphorylates RNA polymerase II, releasing it from the general factors so it can begin the elongation phase of transcription. As shown, the site of phosphorylation is a long polypeptide tail that extends from the polymerase molecule.

Anmerkungen

The figure is sufficiently referenced, but it is not clear to the reader that the extensive caption is also taken verbatim from the source.

Sichter
(Hindemith) Schumann

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