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Quelle:Rlm/Gordon et al 2010

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Angaben zur Quelle [Bearbeiten]

Autor     Vicki Gordon, Shriti Bhadel, Winfried Wunderlich, JoAnn Zhang, Scott B. Ficarro, Sahana A. Mollah, Jeffrey Shabanowitz, Donald F. Hunt, Ioannis Xenarios, William C. Hahn, Mark Conaway, Michael F. Carey, and Daniel Gioeli
Titel    CDK9 Regulates AR Promoter Selectivity and Cell Growth through Serine 81 Phosphorylation
Zeitschrift    Molecular Endocrinology
Ausgabe    24
Datum    27. October 2010
Seiten    2267–2280
DOI    10.1210/me.2010-0238
URL    http://press.endocrine.org/doi/abs/10.1210/me.2010-0238

Literaturverz.   

yes
Fußnoten    yes
Fragmente    3


Fragmente der Quelle:
[1.] Rlm/Fragment 042 03 - Diskussion
Zuletzt bearbeitet: 2014-12-06 18:57:34 SleepyHollow02
Fragment, Gesichtet, Gordon et al 2010, KeineWertung, Rlm, SMWFragment, Schutzlevel

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Graf Isolan
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Untersuchte Arbeit:
Seite: 42, Zeilen: 3-6
Quelle: Gordon et al 2010
Seite(n): 2267, Zeilen: 17-19
The role of Ser81 has been widely studied, recently according to our data Gioeli et al. discovered that LHS cells stably expressing wild-type and S81A mutant AR showed differences in the regulation of endogenous AR target genes, suggesting that S81 phosphorylation regulates promoter selectivity. LHS cells stably expressing wild-type and S81A mutant AR showed differences in the regulation of endogenous AR target genes, suggesting that S81 phosphorylation regulates promoter selectivity.
Anmerkungen

Although from some point onward identical, nothing has been marked as a citation.

Gioeli is one of the co-authors of Gordon et al 2010.

Sichter
(Graf Isolan), SleepyHollow02

[2.] Rlm/Fragment 043 09 - Diskussion
Zuletzt bearbeitet: 2014-12-06 20:09:49 Singulus
BauernOpfer, Fragment, Gesichtet, Gordon et al 2010, Rlm, SMWFragment, Schutzlevel sysop

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Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 43, Zeilen: 9-17
Quelle: Gordon et al 2010
Seite(n): 2267, Zeilen: 21 ff.
Recently Gioeli et.al found an association between (CDK)9 and AR. CDK9 phosphorylates the AR on Ser81 in vitro. Phosphorylation is specific to AR Ser81 because CDK9 did not phosphorylate the AR on other serine phosphorylation sites. Overexpression of CDK9 with its cognate cyclin, Cyclin T, increased Ser81 phosphorylation levels in cells. Small interfering RNA knockdown of CDK9 protein levels decreased hormone-induced S81 phosphorylation. Additionally, treatment of LNCaP cells with the CDK9 inhibitors, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and Flavopiridol, reduced [Ser81 phosphorylation further, suggesting that CDK9 regulates Ser81 phosphorylation.] We observed cyclin-dependent kinase (CDK)9 association with the AR. CDK9 phosphorylates the AR on S81 in vitro. Phosphorylation is specific to S81 because CDK9 did not phosphorylate the AR on other serine phosphorylation sites. Overexpression of CDK9 with its cognate cyclin, Cyclin T, increased S81 phosphorylation levels in cells. Small interfering RNA knockdown of CDK9 protein levels decreased hormone-induced S81 phosphorylation. Additionally, treatment of LNCaP cells with the CDK9 inhibitors, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and Flavopiridol, reduced S81 phosphorylation further, suggesting that CDK9 regulates S81 phosphorylation.
Anmerkungen

Although nearly identical, nothing has been marked as a citation. It is not clear which work of Gioeli Rlm refers to. Is this vagueness intentional?

Gioeli is one of the co-authors of Gordon et al 2010.

Sichter
(Graf Isolan), SleepyHollow02

[3.] Rlm/Fragment 044 01 - Diskussion
Zuletzt bearbeitet: 2014-12-06 20:08:29 Singulus
BauernOpfer, Fragment, Gesichtet, Gordon et al 2010, Rlm, SMWFragment, Schutzlevel sysop

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BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 44, Zeilen: 1-6
Quelle: Gordon et al 2010
Seite(n): 2267, Zeilen: 26-31
[Additionally, treatment of LNCaP cells with the CDK9 inhibitors, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and Flavopiridol, reduced] Ser81 phosphorylation further, suggesting that CDK9 regulates Ser81 phosphorylation. Pharmacological inhibition of CDK9 also resulted in decreased AR transcription in LNCaP cells. Collectively these results suggest that CDK9 phosphorylation of AR Ser81 is an important step in regulating AR transcriptional activity and prostate cancer cell growth. Additionally, treatment of LNCaP cells with the CDK9 inhibitors, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and Flavopiridol, reduced S81 phosphorylation further, suggesting that CDK9 regulates S81 phosphorylation. Pharmacological inhibition of CDK9 also resulted in decreased AR transcription in LNCaP cells. Collectively these results suggest that CDK9 phosphorylation of AR S81 is an important step in regulating AR transcriptional activity and prostate cancer cell growth.
Anmerkungen

Continues from the previous page. Although nearly identical, nothing has been marked as a citation.

Gioeli is one of the co-authors of Gordon et al 2010.

Sichter
(Graf Isolan), SleepyHollow02

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