Fandom

VroniPlag Wiki

Quelle:Rlm/Narayanan et al 2010

< Quelle:Rlm

31.381Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.

Angaben zur Quelle [Bearbeiten]

Autor     Ramesh Narayanan, Muralimohan Yepuru, Adam T. Szafran, Maria Szwarc, Casey E. Bohl, Natalie L. Young, Duane D. Miller, Michael A. Mancini, and James T. Dalton
Titel    Discovery and Mechanistic Characterization of a Novel Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer
Zeitschrift    Cancer Research
Ausgabe    70
Datum    12. January 2010
Seiten    842-851
Anmerkung    PubMed: PMID 20068182
DOI    10.1158/0008-5472.CAN-09-3206
URL    http://cancerres.aacrjournals.org/content/70/2/842.full.pdf+html

Literaturverz.   

yes
Fußnoten    yes
Fragmente    2


Fragmente der Quelle:
[1.] Rlm/Fragment 020 06 - Diskussion
Zuletzt bearbeitet: 2014-12-01 17:34:29 Singulus
BauernOpfer, Fragment, Gesichtet, Narayanan et al 2010, Rlm, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 20, Zeilen: 6-10
Quelle: Narayanan et al 2010
Seite(n): 842, Zeilen: 12-15
Recently Narayanan et al. discovered a selective nuclear androgen receptor exporter (SNARE) that functions to exclude AR from the nucleus. SNARE-1 binds wild-type and mutant ARs and efficiently inhibits their transactivation activity and ability to induce PSA gene expression. Here, we report the discovery of a selective nuclear androgen receptor exporter (SNARE) that functions to exclude AR from the nucleus. SNARE-1 binds wild-type and mutant ARs and efficiently inhibits their transactivation activity and ability to induce PSA gene expression.
Anmerkungen

Taken verbatim from the original source, continued on next page. Alhough the authors were mentioned, it has not been marked that the take-over has been word by word.

Sichter
(Graf Isolan), SleepyHollow02

[2.] Rlm/Fragment 021 01 - Diskussion
Zuletzt bearbeitet: 2014-12-02 08:18:35 Singulus
BauernOpfer, Fragment, Gesichtet, Narayanan et al 2010, Rlm, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 21, Zeilen: 1-8
Quelle: Narayanan et al 2010
Seite(n): 842, Zeilen: 15-19
SNARE-1 inhibits the androgen-sensitive growth of LNCaP cells and tumor xenografts. Quantitative subcellular localization studies suggest that SNARE-1 inhibits nuclear translocation of AR, but also facilitates export of nuclear AR that has been translocated by an agonist. Mechanistic studies indicate that SNARE-1 rapidly phosphorylates p38 mitogen-activated protein kinase (MAPK) and Ser650 of the AR facilitating the nuclear export of AR. Additionally, SNARE-1 was found to promote ubiquitination of AR in LNCaP cells (30).

30) Ramesh Narayanan, Muralimohan Yepuru, Adam T. Szafran, Maria Szwarc, Casey E. Bohl, Natalie L. Young, Duane D. Miller, Michael A. Mancini, and James T. Dalton. Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer. Cancer Research 2010 Jan 15;70(2):842-51. Epub 2010 Jan 12.

SNARE-1 inhibits the androgen-sensitive growth of LNCaP cells and tumor xenografts. Quantitative subcellular localization studies suggest that SNARE-1 inhibits nuclear translocation of AR, but also facilitates export of nuclear AR that has been translocated by an agonist. Mechanistic studies indicate that SNARE-1 rapidly phosphorylates p38 mitogen-activated protein kinase (MAPK) and Ser650 of the AR. Additionally, SNARE-1 was found to promote ubiquitination of AR in LNCaP cells.
Anmerkungen

Taken verbatim from the original source, continued from previous page. Alhough the authors are mentioned here, it has not been marked that the take-over has been word by word.

Sichter
(Graf Isolan), SleepyHollow02

Auch bei Fandom

Zufälliges Wiki