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Quelle:Rlm/Ryo et al 2005

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Angaben zur Quelle [Bearbeiten]

Autor     Akihide Ryo, Hiroji Uemura, Hitoshi Ishiguro, Tatsuya Saitoh, Akira Yamaguchi, Kilian Perrem, Yoshinobu Kubota, Kun Ping Lu, and Ichiro Aoki
Titel    Stable Suppression of Tumorigenicity by Pin1-Targeted RNA Interference in Prostate Cancer
Zeitschrift    Clinical Cancer Research
Ausgabe    11
Datum    15. Oktober 2005
Nummer    20
Seiten    7523-7531
DOI    10.1158/1078-0432.CCR-05-0457
URL    http://clincancerres.aacrjournals.org/content/11/20/7523

Literaturverz.   

no
Fußnoten    no
Fragmente    2


Fragmente der Quelle:
[1.] Rlm/Fragment 033 02 - Diskussion
Zuletzt bearbeitet: 2014-12-06 20:06:41 Singulus
BauernOpfer, Fragment, Gesichtet, Rlm, Ryo et al 2005, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 33, Zeilen: 2-3, (5-7), 7-20
Quelle: Ryo et al 2005
Seite(n): 7523, Zeilen: 5-6, 8-16
It is now clear that Pin1plays [sic] a catalytic role in oncogenesis in solid cancers. [...] RYO et al. have already suggested PIN1 like a good target for patients with prostate cancer with different kind of experiments. In those studies a retrovirus-mediated RNA interference targeting Pin1was [sic] expressed in PC3 and LNCaP cells, and cell growth and several transformed properties were investigated.

As result the stable expression of Pin1-specific small interfering RNA constructs in PC3 and LNCaP cells significantly reduced cellular proliferation, colony formation, migration, and invasion but strongly enhanced the apoptotic response induced by serum depletion or treatment with anticancer agents. Furthermore, Pin1depletion [sic] significantly suppressed tumorigenic potential in athymicmice [sic], resulting in the inhibition of both tumor growth and angiogeneisis.

These results strongly suggest that Pin1plays [sic] an important role not only in tumorigenesis but also in the maintenance of the transformed phenotype in prostate cancer cells.

Abstract

Purpose: The peptidyl-prolyl isomrase Pin1plays [sic] a catalytic role in oncogenesis in solid cancers, including prostate cancer. [...]

Experimental Design: A retrovirus-mediated RNA interference targeting Pin1was [sic] expressed in PC3 and LNCaP cells, and cell growth and several transformed properties were investigated.

Results: The stable expression of Pin1-specific small interfering RNA constructs in PC3 and LNCaPce lls significantly reduced cellular proliferation, colony formation, migration, and invasion but strongly enhanced the apoptotic response induced by serum depletion or treatment with anticancer agents. Furthermore, Pin1depletion [sic] significantly suppressed tumorigenic potential in athymic mice, resulting in the inhibition of both tumor growth and angiogeneisis.

Conclusions: These results strongly suggest that Pin1plays [sic] an important role not only in tumorigenesis but also in the maintenance of the transformed phenotype in prostate cancer cells.

Anmerkungen

Although identical, nothing has been marked as a citation.

Though "RYO et al." is named as some kind of reference, the article, where this passage comes from, is not to be found in Rlm's list of references.

Sichter
(Graf Isolan), SleepyHollow02

[2.] Rlm/Fragment 034 16 - Diskussion
Zuletzt bearbeitet: 2014-12-04 20:20:58 SleepyHollow02
BauernOpfer, Fragment, Rlm, Ryo et al 2005, SMWFragment, Schutzlevel, ZuSichten

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Bearbeiter
SleepyHollow02
Gesichtet
No.png
Untersuchte Arbeit:
Seite: 34, Zeilen: 16-18
Quelle: Ryo et al 2005
Seite(n): 7523, Zeilen: right col.: 31 ff..
Ayala et al. have shown that Pin1 expression levels were tightly correlated with both a higher probability and a shorter period of tumor recurrence following radical [prostatectomy by a comprehensive immunohistochemical analysis.] Ayala et al. (12) have shown that Pin1 expression levels were tightly correlated with both a higher probability and a shorter period of tumor recurrence following radical prostatectomy by a comprehensive immunohistochemical analysis.

12. Ayala G,Wang D,Wulf G, et al.The prolyl isomerase Pin1is a novel prognostic marker in human prostate cancer. Cancer Res 2003;63:6244^51.

Anmerkungen
Sichter
(SleepyHollow02)

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