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Angaben zur Quelle [Bearbeiten]

Autor     I. D'Errico, A. Moschetta
Titel    Nuclear receptors, intestinal architecture and colon cancer: an intriguing link
Zeitschrift    Cellular and Molecular Life Sciences
Ort    Basel
Verlag    Birkhäuser Verlag
Ausgabe    65
Datum    16. Februar 2008
Seiten    1523 – 1543
ISSN    1420-682X (print), 1420-9071 (online)
DOI    10.1007/s00018-008-7552-1
URL    http://link.springer.com/article/10.1007/s00018-008-7552-1

Literaturverz.   

ja
Fußnoten    nein
Fragmente    1


Fragmente der Quelle:
[1.] Shg/Fragment 023 04 - Diskussion
Zuletzt bearbeitet: 2014-11-02 20:06:49 Hindemith
DErrico und Moschetta 2008, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Shg, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 23, Zeilen: 4-21
Quelle: DErrico und Moschetta 2008
Seite(n): 1534, Zeilen: li.Sp. 43-47, re.Sp. 11-18.21-35
1.2.4. Colon cancer and steroid receptors

Although colon cancer is not a hormone-dependent tumor, the existence of sex differences in colon cancer incidence was proposed several years ago. The activity of steroid receptor plays a pivotal role in a well-controlled cascade of signals, which maintains the mucosal architecture by the shedding of senescent and apoptotic cells at the surface of the epithelium. The identification of a functional interaction between the Wnt/APC pathway and steroid represents a major goal for several laboratories [Mulholland, et al 2005]. β-Catenin activates a growing number of steroid receptors, resulting in alterations of cell proliferation and tumorigenesis. On the other hand, Wnt signaling appears to be compromised by the action of some steroid receptors. It is also clear that steroid receptors are regionally compartmentalized along the cryptvillus axis, determining the switching on and off of transcription of particular genes with a strong influence on cell fate. The mechanism for the influence of steroid receptors on cell proliferation, differentiation and apoptosis in the gut is complex and still under investigation. Also, the observed phenotypes after steroid receptor activation or inhibition are sometimes contradictory. Steroid receptor effects depend on the amount of agonists, the cell type and the mutational. [Mulholland, et al. 2005]


Mulholland, D. J., Dedhar, S., Coetzee, G. A. and Nelson, C. C. (2005). Interaction of nuclear receptors with the Wnt/ beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr. Rev. 26, 898–915.

The existence of sex differences in colon cancer incidence was proposed several years ago, due to the observation that this neoplasia occurs more often in men than in women in nearly all countries [256]. [...]

[...]

[...] A well-controlled cascade of signals maintains the mucosal architecture by the shedding of senescent and apoptotic cells at the surface of the epithelium. The activity of some NRs seems to play a pivotal role in this process. The identification of a functional interaction between the Wnt/APC pathway and NRs represents a major goal for several laboratories [260]. [...] What we know today is that β-catenin activates a growing number ofNRs, resulting in alterations of cell proliferation and tumorigenesis. On the other hand, Wnt signaling appears to be compromised by the action of some NRs. It is also clear that NRs are regionally compartmentalized along the cryptvillus axis, determining the switching on and off of transcription of particular genes with a strong influence on cell fate. The mechanism for the influence of NRs on cell proliferation, differentiation and apoptosis in the gut is complex and still under investigation. Also, the observed phenotypes after NR activation or inhibition are sometimes contradictory. NR effects depend on the amount of agonists, on the cell type and on the mutational events that predispose cells to cancer development.


256 Haenszel, W. and Correa, P. (1971) Cancer of the colon and rectum and adenomatous polyps. A review of epidemiologic findings. Cancer 28, 14–24.

260 Mulholland, D. J., Dedhar, S., Coetzee, G. A. and Nelson, C. C. (2005) Interaction of nuclear receptors with the Wnt/ beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr. Rev. 26, 898–915.

Anmerkungen

Ohne Hinweis auf eine Übernahme. Der letzte Satz bricht unvermittelt ab und wird so teilweise unverständlich. In der ungenannt bleibenden Quelle liegt der Satz in unverstümmelter Form vor. "NR" in der Quelle steht für "Nuclear receptor". Die Referenz zu Mulholland et al 2005 wurde aus dem Literaturverzeichnis der Quelle kopiert - das überzählige Leerzeichen zwischen "/" und "beta-catenin/" (was sich dahinter nicht findet) entspringt einem Zeilenumbruch im Original.

Mulholland, et al. (2005) enthält den Text nicht.

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(Graf Isolan), Hindemith

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