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Autor     Peter B. Dirks
Titel    Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer
Zeitschrift    Journal of Clinical Oncology
Herausgeber    American Society of Clinical Oncology
Ausgabe    26
Jahr    2008
Seiten    2916-2924
DOI    10.1200/JCO.2008.17.6792
URL    http://jco.ascopubs.org/content/26/17/2916.abstract

Literaturverz.   

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Fußnoten    nein
Fragmente    2


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[1.] Src/Fragment 016 01 - Diskussion
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Dirks 2008, Fragment, SMWFragment, Schutzlevel, Src, Verschleierung, ZuSichten

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CD133 positive human glioblastoma cells were shown to be resistant to radiation therapy, retaining a clonogenic and tumorigenic potential. CD133 positive cells increase in number after irradiation of glioblastoma cells in culture and in tumors growing in vivo. The CD133 positive cells undergo similar DNA damage to those of their CD133 negative counterparts, but they show a better ability to repair strand breaks, through a more potent activation of DNA damage checkpoint mechanisms (Bao, S. et al, 2006). In work by the Rich group,24 CD133+ humanglioblastoma cells were shown to be resistant to radiation therapy, retaining a clonogenic and tumorigenic potential. CD133+ cells increase in number after irradiation of glioblastomas cells in culture and in tumors growing in vivo. The CD133+ cells undergo similar DNA damage to those of their CD133– counterparts, but they show a better ability to repair strand breaks, through a more potent activation of DNA-damage checkpoint mechanisms.

24. Bao S, Wu Q, McLendon RE, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760, 2006

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Bao, S. et al, 2006 enthält den Text nicht.

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[2.] Src/Fragment 018 12 - Diskussion
Zuletzt bearbeitet: 2014-09-27 20:22:13 Kybot
Dirks 2008, Fragment, SMWFragment, Schutzlevel, Src, Verschleierung, ZuSichten

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Promotion of tumor stem-cell differentiation may be an important strategy for treatment of brain tumor stem cells. Bone morphogenic proteins (BMPs), which normally induce astrocyte differentiation from normal neural precursors, have been shown to promote glioblastoma cell differentiation in vitro and in vivo. Most importantly, recombinant BMPs induce the suppression of glioblastoma tumorigenicity in vivo, possibly though promotion of the differentiation cancer stem cells in the tumor (Piccirillo, S.G., et al 2006). Promotion of tumor stem-cell differentiation may be an important strategy for treatment of brain tumor stem cells. Vescovi et al26 have shown that bone morphogenic proteins (BMPs), which normally induce astrocyte differentiation from normal neural precursors, have been shown to promote glioblastoma cell differentiation in vitro and in vivo. Most importantly, BMPs induce the suppression of glioblastoma tumorigenicity in vivo, possibly though promotion of the differentiation of restricted tumor progenitors or by direct action on the most primitive cell (the cancer stem cell) in the tumor.

26. Piccirillo SG, Reynolds BA, Zanetti N, et al: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444:761-765, 2006

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Piccirillo, S.G., et al 2006 enthält den Text nicht.

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