Fandom

VroniPlag Wiki

Quelle:Src/Visser 2005

< Quelle:Src

31.368Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.

Angaben zur Quelle [Bearbeiten]

Autor     Corine Visser
Titel    The Transferrin Receptor at the Blood-Brain Barrier - exploring the possibilities for brain drug delivery
Ort    Leiden
Jahr    2005
Anmerkung    Doctoral thesis, Leiden University
URL    https://openaccess.leidenuniv.nl/handle/1887/586

Literaturverz.   

nein
Fußnoten    nein
Fragmente    1


Fragmente der Quelle:
[1.] Src/Fragment 023 02 - Diskussion
Zuletzt bearbeitet: 2014-09-27 20:22:19 Kybot
Fragment, KomplettPlagiat, SMWFragment, Schutzlevel, Src, Visser 2005, ZuSichten

Typus
KomplettPlagiat
Bearbeiter
Hindemith
Gesichtet
No.png
Untersuchte Arbeit:
Seite: 23, Zeilen: 2-14
Quelle: Visser 2005
Seite(n): 21, 22, Zeilen: 21: 14ff; 22: 1ff
The expression level of the TfR depends on the level of iron supply and rate of cell proliferation. The iron concentration determines TfR synthesis and expression via an iron-responsive element (IRE) in the mRNA of the TfR (Kuhn, L. C. et al, 1991, Casey, J. L. et al, 1989). This IRE is also found in the mRNA of ferritin, a protein that can store iron (Kuhn, L. C. et al, 1991). In cases of low iron concentrations, a so called IRE binding protein stabilises the mRNA of the TfR, which can therefore be translated. The mRNA of ferritin is in low-iron situations less stable and is therefore translated to a lesser extent. Recently, a second TfR (TfR-2) has been identified (Trinder, D. and Baker, E. et al, 2003), which does not contain an IRE in its mRNA. TfR-2 is differentially distributed from TfR and has a 25-fold lower affinity for Tf.

The TfR is expressed mainly on hepatocytes, erythrocytes, intestinal cells, monocytes, as well as on endothelial cells of the BBB [...] (Morgan, E. [H. et al, 1996, Ponka, P. and Lok, C. N. et al, 1999).]

The TfR is expressed mainly on hepatocytes, erythrocytes, intestinal cells, monocytes, as well as on endothelial cells of the BBB (34, 35).

[Seite 22]


The expression level of the TfR depends on the level of iron supply and rate of cell proliferation. [...] The iron concentration determines TfR synthesis and expression via an iron-responsive element (IRE) in the mRNA of the TfR (37, 38). This IRE is also found in the mRNA of ferritin, a protein that can store iron (37). In cases of low iron concentrations, a so-called IRE binding protein stabilises the mRNA of the TfR, which can therefore be translated. The mRNA of ferritin is in low-iron situations less stable and is therefore translated to a lesser extent.

Recently, a second TfR (TfR-2) has been identified (39), which does not contain an IRE in its mRNA. TfR-2 is differentially distributed from TfR and has a 25-fold lower affinity for Tf.


34. Morgan, E. H. (1996) Iron metabolism and transport. In Hepatology. A textbook of liver disease, Vol. 1 (D. Zakin and T. D. Boyer, eds.), Saunders, Philadelphia, pp. 526-554

35. Ponka, P. and Lok, C. N. (1999) The transferrin receptor: role in health and disease. Int J Biochem Cell Biol 31 (10): 1111-1137

37. Kuhn, L. C. (1991) mRNA-protein interactions regulate critical pathways in cellular iron metabolism. Br J Haematol 79 (1): 1-5

38. Casey, J. L., Koeller, D. M., Ramin, V. C., Klausner, R. D. and Harford, J. B. (1989) Iron regulation of transferrin receptor mRNA levels requires iron- responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. Embo J 8 (12): 3693-3699

39. Trinder, D. and Baker, E. (2003) Transferrin receptor 2: a new molecule in iron metabolism. Int J Biochem Cell Biol 35 (3): 292-296

Anmerkungen

Ein Verweis auf die Quelle fehlt.

Sichter
(Hindemith)

Auch bei Fandom

Zufälliges Wiki