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| Autor | Catriona H.M. Jamieson, Irving L. Weissman, Emmanuelle Passegué |
| Titel | Chronic versus acute myelogenous leukemia: A question of self-renewal |
| Zeitschrift | Cancer Cell |
| Datum | December 2004 |
| Seiten | 531-533 |
| URL | http://www.sciencedirect.com/science/article/pii/S1535610804003423 |
Literaturverz. |
yes |
| Fußnoten | yes |
| Fragmente | 2 |
| [1.] Vpr/Fragment 004 10 - Diskussion Zuletzt bearbeitet: 2014-04-04 23:00:39 Hindemith | BauernOpfer, Fragment, Gesichtet, Jamieson et al 2004, SMWFragment, Schutzlevel sysop, Vpr |
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| Untersuchte Arbeit: Seite: 4, Zeilen: 10-17 |
Quelle: Jamieson et al 2004 Seite(n): 531, Zeilen: col 1: 1-11 |
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| Human cancer stem cells, identified in acute myelogenous leukemia (AML) (Bonnet and Dick, 1997), myeloid blast crisis of chronic myelogenous leukemia (Jamieson et. al., 2004), breast cancer and brain tumors (Al-Hajj et. al., 2003; Singh et. al., 2003) share functional properties with normal stem cells such as self-renewal, high proliferative potential, some differentiation capacity and ability to be serially transplanted (Jamieson et. al., 2004b; Passegue et. al., 2003).
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., and Clarke, M. F. (2003). Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100, 3983-3988. Bonnet, D., and Dick, J. E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3, 730-737. Jamieson, C. H., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004a). Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351, 657- 667. Jamieson, C. H., Weissman, I. L., and Passegue, E. (2004b). Chronic versus acute myelogenous leukemia; A question of self-renewal. Cancer Cell 6, 531-533. Passegue, E., Jamieson, C. H., Ailles, L. E., and Weissman, I. L. (2003). Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A 100 Suppl 1, 11842-11849. Singh, S. K., Clarke, I. D., Terasaki, M., Bonn, V. E., Hawkins, C., Squire, J., and Dirks, P. B. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63, 5821-5828. |
Human cancer stem cells, identified in acute myelogenous leukemia (Bonnet and Dick, 1997), myeloid blast crisis of chronic myelogenous leukemia (Jamieson et al, 2004), breast cancer (Al-Hajj et al., 2003), and brain tumors (Singh et al., 2003), share functional properties with normal stem cells, such as high proliferative potential, some differentiation capacity, and the ability to be serially transplanted (reviewed in Passegué et al., 2003).
Al-Hajj, M., Wicha, M., Benito-Hernandez, A., Morrison, S., and Clarke, M. (2003). Proc. Natl. Acad. Sci. USA 100, 3983–3988. Bonnet, D., and Dick, J.E. (1997). Nat. Med. 3, 730–737. Jamieson, C.H., Ailles, L.E., Dylla, S.J., Muijtjens, M., Jones, C., Zehnder, J.L., Gotlib, J., Li, K., Manz, M.G., Keating, A., et al. (2004). N. Engl. J. Med. 351, 657–667. Passegué, E., Jamieson, C.H.M., Ailles, L.E., and Weissman, I.L. (2003). Proc. Natl. Acad. Sci. USA 100, 11842–11849. Singh, S.K., Clarke, I.D., Terasaki, M., Bonn, V.E., Hawkins, C., Squire, J., and Dirks, P.B. (2003). Cancer Res. 63, 5821–5828. |
The source is mentioned, but it is not clear that the overview of the literature is taken from it. The reader rather assumes that the given source is just one more reference. |
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| [2.] Vpr/Fragment 005 09 - Diskussion Zuletzt bearbeitet: 2014-04-04 23:00:43 Hindemith | BauernOpfer, Fragment, Gesichtet, Jamieson et al 2004, SMWFragment, Schutzlevel sysop, Vpr |
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| Untersuchte Arbeit: Seite: 5, Zeilen: 9-22 |
Quelle: Jamieson et al 2004 Seite(n): 532, Zeilen: figure |
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Figure 3. Oncogene hierarchy and role of self-renewal in the pathogenesis of leukemias. A. Normal myelopoiesis is distinguished by the orderly differentiation of HSC, which are the only cells with self-renewal capacity, into committed myeloid progenitors and their respective terminally differentiated progeny. B. Chronic diseases, such as chronic phase CML, are associated with preleukemic events that result in increased survival and proliferation within the stem and myeloid progenitor populations but continued production of terminally differentiated progeny. Acquisition of BCR-ABL, overexpression of BCL2, and inactivation of JunB expression are examples of such events that initially take place in HSC. C and D: Acute diseases such as blast crisis CML and AML are marked by acquisition of self-renewal capacity by progenitors that normally lack it or by enhanced self-renewal in HSC. β-catenin activation during the progression of CML to blast crisis is an example of such a leukemogenic event occurring in myeloid progenitors. MOZ-TIF2 and MLL-ENL are AML-associated translocation products that may enhance HSC self-renewal or endow myeloid progenitors with self-renewal potential. Together with a subsequent block in differentiation, these leukemogenic [events result in the accumulation of immature blast progeny and development of AML at either the HSC or myeloid progenitor stage (Figure adapted from Jamieson et. al., 2004b) .] |
Figure 1. Oncogene hierarchy and role of self-renewal in pathogenesis of leukemias A: Normal myelopoiesis is distinguished by the orderly differentiation of hematopoietic stem cells (HSC), which are the only cells with self-renewal capacity, into committed myeloid progenitors and their respective terminally differentiated progeny. B: Chronic diseases, such as chronic phase CML, are associated with preleukemic events that result in increased survival and proliferation within the stem and myeloid progenitor populations but continued production of terminally differentiated progeny. Acquisition of BCR-ABL, overexpression of Bcl2, and inactivation of JunB expression are examples of such events that initially take place in HSC. C and D: Acute diseases such as blast crisis CML and AML are marked by acquisition of self-renewal capacity by progenitors that normally lack it or by enhanced self-renewal in HSC. β-catenin activation during the progression of CML to blast crisis is an example of such a leukemogenic event occurring in myeloid progenitors. MOZ-TIF2 and MLL-ENL are AML-associated translocation products that may enhance HSC self-renewal or endow myeloid progenitors with self-renewal potential. Together with a subsequent block in differentiation, these leukemogenic events result in the accumulation of immature blast progeny and development of AML at either the HSC or myeloid progenitor stage. |
The source is mentioned: "Figure adapted from Jamieson et. al., 2004b", but is not clear to the reader that "adapted from" actually means "copied from" and that also the very extensive figure caption has been copied 1-to-1. |
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