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Angaben zur Quelle [Bearbeiten]

Autor     Bronwyn M. Owens, Robert G. Hawley
Titel    HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis
Zeitschrift    Stem Cells
Ausgabe    20
Jahr    2002
Seiten    364-379
URL    http://onlinelibrary.wiley.com/doi/10.1634/stemcells.20-5-364/pdf

Literaturverz.   

yes
Fußnoten    yes
Fragmente    4


Fragmente der Quelle:
[1.] Vpr/Fragment 006 16 - Diskussion
Zuletzt bearbeitet: 2014-04-05 07:37:56 Hindemith
BauernOpfer, Fragment, Gesichtet, Owens and Hawley 2002, SMWFragment, Schutzlevel sysop, Vpr

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Sequences flanking the HD also influence specificity by coordinating interaction with cofactor proteins that influence DNA-binding properties. Homeobox genes are divided into two classes. [...] (Abate-Shen, 2002; Owens and Hawley, 2002) Sequences flanking the HD also influence specificity by coordinating interaction with cofactor proteins that influence DNA-binding properties.

HD encoding (homeobox [HB]) genes are broadly divided into two classes.

Anmerkungen

The source is mentioned two sentences further down, but it is not clear that this reference applies to the here documented sentence, and it is also not clear that Owens and Hawley are quoted literally here.

Sichter
(Hindemith) Schumann

[2.] Vpr/Fragment 008 27 - Diskussion
Zuletzt bearbeitet: 2014-04-05 07:41:40 Hindemith
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The function of HOX genes in hematopoiesis has been investigated through knockout mouse models and overexpression from retroviral vectors in hematopoietic stem cells from murine fetal liver and bone marrow and in human cord blood progenitors. The function of HOX genes in hematopoiesis has been investigated through knockout mouse models and enforced overexpression from retroviral vectors in hematopoietic stem cells from murine fetal liver and bone marrow and in human cord blood progenitors.
Anmerkungen

The source is not mentioned.

Sichter
(Hindemith) Schumann

[3.] Vpr/Fragment 010 09 - Diskussion
Zuletzt bearbeitet: 2014-04-04 23:00:47 Hindemith
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1.3.2 Non-clustered homeobox genes in leukemogenesis

Several non-clustered HD proteins have been shown to function as cofactors for HOX proteins, interacting with HOX genes by a conserved sequence YPWMK and are co-expressed during embryonic development. These include the three-amino-acid-loop-extension (TALE) proteins, PBX, MEIS, and PREP1/KNOX1. PBX genes are widely expressed in fetal and adult tissues, although PBX1 transcripts are notably absent from lymphocytes (Monica et. al., 1991). The hematopoietically expressed (HEX) gene as another example of a non-clustered homeobox gene was initially identified in human hematopoietic cells, where it is expressed in multipotential progenitors, myeloid cells, and B cells, but not T or erythroid cells (Bedford et. al., 1993). HEX expression has also been detected in peripheral blood leukocytes from leukemia patients (Manfioletti et. al., 1995). Other non-HOX HB genes like HOX11, and members of the CDX, HLX, and PMX1 families are more restricted in their patterns of expression, and are involved in organogenesis or differentiation of specific cell types.

[page 365]

Several non-HOX HD proteins have been shown to function as cofactors for HOX proteins and are cosynthesized during embryonic development. These include the three-amino-acid-loop-extension (TALE) proteins, PBX, MEIS, and PREP1/KNOX1. PBX genes are widely expressed in fetal and adult tissues, although PBX1 transcripts are notably absent from lymphocytes [28]. [...]

Other non-HOX HB genes are more restricted in their patterns of expression, and their encoded HD proteins are involved in organogenesis or differentiation of specific cell types.

[page 371]

HEX (hematopoietically expressed HB; Hhex/Prh) was initially identified in human hematopoietic cells, where it is expressed in multipotential progenitors, myeloid cells, and B cells, but not T or erythroid cells [127]. HEX expression has also been detected in peripheral blood leukocytes from leukemia patients [127, 128]


28 Monica K, Galili N, Nourse J et al. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol 1991;11:6149-6157.

127 Bedford FK, Ashworth A, Enver T et al. HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res 1993;21:1245-1249.

128 Manfioletti G, Gattei V, Buratti E et al. Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells. Blood 1995;85:1237-1245.

Anmerkungen

The only reference to the source is made on p.6.

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(SleepyHollow02) Schumann

[4.] Vpr/Fragment 011 01 - Diskussion
Zuletzt bearbeitet: 2014-03-17 12:28:53 Graf Isolan
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1.3.2.1 TALE homeobox genes

Members of the TALE family of non-HOX HD cofactor proteins, which include PBX, MEIS, and PREP1/KNOX1 proteins, are distinguished from other HD proteins by the inclusion of an additional three amino acids between α- helices 1 and 2 within the HD. Evidence from mouse models and human leukemic cells has indicated that inappropriate expression of TALE cofactors with certain HD proteins may contribute to leukemic transformation, while overexpression of TALE cofactors alone does not lead to disease development. One of these proteins, PBX1, has oncogenic potential in the form of a fusion protein with E2A. The PBX1 gene was originally identified at the breakpoint of the t(1;19) translocation found in 10 to 20% of childhood pre-B-cell ALL (Shikano et. al., 1999).

Members of the TALE family of non-HOX HD cofactor proteins, which include PBX, MEIS, and PREP1/KNOX1 proteins, are distinguished from other HD proteins by the inclusion of an additional three amino acids between α-helices 1 and 2 within the HD. Evidence from mouse models and human leukemic cells has indicated that inappropriate expression of TALE cofactors with certain HD proteins may contribute to leukemic transformation, while overexpression of TALE cofactors alone does not lead to disease development. However, as noted above and discussed in detail below, one of these proteins, PBX1, has oncogenic potential in the form of a fusion protein with E2A. The PBX1 gene was originally identified at the breakpoint of the t(1;19) translocation found in childhood pre-B-cell ALL [29, 30]

29 Kamps MP, Murre C, Sun XH et al. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 1990;60:547-555.

30 Nourse J, Mellentin JD, Galili N et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 1990;60:535-545.

Anmerkungen

The source is not mentioned.

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(SleepyHollow02) Schumann

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