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Titel    Small interfering RNA
Verlag    (Wikipedia)
Jahr    2007
URL    http://en.wikipedia.org/w/index.php?title=Small_interfering_RNA&oldid=147644067

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Fußnoten    nein
Fragmente    2


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[1.] Ww/Fragment 001 13 - Diskussion
Zuletzt bearbeitet: 2014-10-28 02:51:08 Hindemith
Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Verschleierung, Wikipedia Small interfering RNA 2007, Ww

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Quelle: Wikipedia Small interfering RNA 2007
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1.1.2 siRNA

Small interfering RNAs (siRNAs), sometimes known as short interfering RNA or silencing RNAs, represent a class of 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology.

siRNAs have a well defined structure: a short (usually 21-nt) double-strand of RNA (dsRNA) with 2-nt 3' overhangs on either end. Each strand has a 5' phosphate group and a 3' hydroxyl (-OH) group. This structure is the result of processing by Dicer, an enzyme that converts either long dsRNA or hairpin RNAs into siRNAs (Baulcombe et al, 1999).

Most notably, siRNAs are involved in the RNA interference (RNAi) pathway [where the siRNA interferes with the expression of a specific gene (Tuschl et al, 2001).]

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway where the siRNA interferes with the expression of a specific gene. [...]

[...]

SiRNAs have a well defined structure: a short (usually 21-nt) double-strand of RNA (dsRNA) with 2-nt 3' overhangs on either end:

[...]

Each strand has a 5' phosphate group and a 3' hydroxyl (-OH) group. This structure is the result of processing by dicer, an enzyme that converts either long dsRNAs or small hairpin RNAs into siRNAs.[3]


3. Bernstein E, Caudy A, Hammond S, Hannon G (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature 409 (6818): 363–6. PMID 11201747.

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[2.] Ww/Fragment 002 01 - Diskussion
Zuletzt bearbeitet: 2014-10-28 02:51:17 Hindemith
Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Verschleierung, Wikipedia Small interfering RNA 2007, Ww

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[Most notably, siRNAs are involved in the RNA interference (RNAi) pathway] where the siRNA interferes with the expression of a specific gene (Tuschl et al, 2001). In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, as an antiviral mechanism or in shaping the chromatin structure of a genome. siRNAs can also be exogenously (artificially) introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest. Essentially any gene of which the sequence is known can thus be targeted based on sequence complementarity with tailored siRNA. This has made siRNA an important tool for gene function and drug target validation studies in the post-genomic era. Most notably, siRNA is involved in the RNA interference (RNAi) pathway where the siRNA interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g. as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

[...]

[...] SiRNAs can also be exogenously (artificially) introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest. Essentially any gene of which the sequence is known can thus be targeted based on sequence complementarity with an appropriately tailored siRNA. This has made siRNAs an important tool for gene function and drug target validation studies in the post-genomic era.

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