von Dott. Raffaele La Montagna
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| [1.] Rlm/Fragment 012 01 - Diskussion Zuletzt bearbeitet: 2014-12-10 23:26:02 Hindemith | Fragment, Gesichtet, Rlm, SABiosciences Androgen Signaling 2009, SMWFragment, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 12, Zeilen: 1 ff. (entire page) |
Quelle: SABiosciences Androgen Signaling 2009 Seite(n): online, Zeilen: - |
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| Inside the nucleus AR interacts with DNA by targeting specific nucleotide palindromic sequences termed Androgen Response Element (17). A number of coregulators themselves perform enzymatic activities such as phosphorylation or acetylation, modifying either the chromatin surrounding the promoter of the target gene or other coregulators. Among coactivators, the acetyltranferase , CBP (CREB Binding Protein) , the closely related p300 and other nuclear receptor coactivators p/CAF(p300/CBP Associated Factor), SRC1( Steroid Receptor Coactivator-1), and SRC3 (18).
17) Petre CE, Wetherill YB, Danielsen M, Knudsen KE. Cyclin D1: mechanism and consequence of androgen receptor co-repressor activity. J Biol Chem 2002 Jan 18;277 (3):2207-15. Epub 2001 Nov 19. 18) Hao Yun Wong, Jan A. Burghoorn, Marije van Leeuwen, Petra E. De Ruiter, Esther Schippers, Leen J. Blok, Ka Wan LI, Henk L. Dekker, Luitzen De Jong, Jan Trapman, J. Anton Grotegoedand Albert O. Btinkmann. Phosphorylation of androgen receptor isoforms.Biochem J. 2004 Oct 15;383(Pt 2):267-76 |
Inside the nucleus, AR interacts with DNA by targeting specific nucleotide palindromic sequences termed ARE (Androgen Response Element) (Ref.2).
A number of coregulators themselves perform enzymatic activities such as phosphorylation or acetylation, modifying either the chromatin surrounding the promoter of the target gene or other coregulators. The prototypic coactivators of this type that possess acetyltransferase activity include, CBP (CREB Binding Protein), the closely related p300 and other nuclear receptor coactivators: p/CAF (p300/CBP Associated Factor), SRC1 (Steroid Receptor Coactivator-1), and SRC3 (Ref.3). 2. Lee DK, Chang C Molecular communication between androgen receptor and general transcription machinery. J Steroid Biochem Mol Biol. 2003 Jan;84(1):41-9. 3. Culig Z, Klocker H, Bartsch G, Steiner H, Hobisch A Androgen Receptors in Prostate Cancer. J Urol. 2003 Oct;170(4):1363-1369. |
The source is not given. Note that Petre et al. (2002) is the reference 4 in the source: 4. Petre CE, Wetherill YB, Danielsen M, Knudsen KE Cyclin D1: mechanism and consequence of androgen receptor co-repressor activity. J Biol Chem. 2002 Jan 18;277(3):2207-15. Epub 2001 Nov 19. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Hindemith, Zeitstempel: 20141210232626