Androgen Receptor and PIN1 in Prostate Cancer
von Dott. Raffaele La Montagna
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| [1.] Rlm/Fragment 013 01 - Diskussion Zuletzt bearbeitet: 2014-12-10 23:28:43 Singulus | Feldman and Feldman 2001, Fragment, Gesichtet, KomplettPlagiat, Rlm, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 13, Zeilen: 1 ff. (komplett) |
Quelle: Feldman and Feldman 2001 Seite(n): 36, Zeilen: Figure 1 |
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| Fig2. Androgen action. Testosterone circulates in the blood bound to albumin (not shown) and sex-hormone-binding globulin (SHBG), and exchanges with free testosterone. Free testosterone enters prostate cells and is converted to dihydrotestosterone (DHT) by the enzyme 5α-reductase. Binding of DHT to the androgen receptor (AR) induces dissociation from heat-shock proteins (HSPs) and receptor phosphorylation. The AR dimerizes and can bind to androgen-response elements in the promoter regions of target genes. Co-activators (such as ARA70) and corepressors (not shown) also bind the AR complex, facilitating or preventing, respectively, its interaction with the general transcription apparatus (GTA). Activation (or repression) of target genes leads to biological responses including growth, survival and the production of prostate-specific antigen (PSA). | Figure 1 Androgen action. Testosterone circulates in the blood bound to albumin (not shown) and sex-hormone-binding globulin (SHBG), and exchanges with free testosterone. Free testosterone enters prostate cells and is converted to dihydrotestosterone (DHT) by the enzyme 5α-reductase. Binding of DHT to the androgen receptor (AR) induces dissociation from heat-shock proteins (HSPs) and receptor phosphorylation. The AR dimerizes and can bind to androgen-response elements in the promoter regions of target genes6. Co-activators (such as ARA70) and corepressors (not shown) also bind the AR complex, facilitating or preventing, respectively, its interaction with the general transcription apparatus (GTA). Activation (or repression) of target genes leads to biological responses including growth, survival and the production of prostate-specific antigen (PSA).
6. Brinkmann, A. O. et al. Mechanisms of androgen receptor activation and function. J. Steroid Biochem. Mol. Biol. 69, 307–313 (1999). |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Singulus, Zeitstempel: 20141210232707
Letzte Bearbeitung dieser Seite: durch Benutzer:Singulus, Zeitstempel: 20141210232707