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Androgen Receptor and PIN1 in Prostate Cancer

von Dott. Raffaele La Montagna

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Statistik und Sichtungsnachweis dieser Seite findet sich am Artikelende
[1.] Rlm/Fragment 033 02 - Diskussion
Zuletzt bearbeitet: 2014-12-06 20:06:41 Singulus
BauernOpfer, Fragment, Gesichtet, Rlm, Ryo et al 2005, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 33, Zeilen: 2-3, (5-7), 7-20
Quelle: Ryo et al 2005
Seite(n): 7523, Zeilen: 5-6, 8-16
It is now clear that Pin1plays [sic] a catalytic role in oncogenesis in solid cancers. [...] RYO et al. have already suggested PIN1 like a good target for patients with prostate cancer with different kind of experiments. In those studies a retrovirus-mediated RNA interference targeting Pin1was [sic] expressed in PC3 and LNCaP cells, and cell growth and several transformed properties were investigated.

As result the stable expression of Pin1-specific small interfering RNA constructs in PC3 and LNCaP cells significantly reduced cellular proliferation, colony formation, migration, and invasion but strongly enhanced the apoptotic response induced by serum depletion or treatment with anticancer agents. Furthermore, Pin1depletion [sic] significantly suppressed tumorigenic potential in athymicmice [sic], resulting in the inhibition of both tumor growth and angiogeneisis.

These results strongly suggest that Pin1plays [sic] an important role not only in tumorigenesis but also in the maintenance of the transformed phenotype in prostate cancer cells.

Abstract

Purpose: The peptidyl-prolyl isomrase Pin1plays [sic] a catalytic role in oncogenesis in solid cancers, including prostate cancer. [...]

Experimental Design: A retrovirus-mediated RNA interference targeting Pin1was [sic] expressed in PC3 and LNCaP cells, and cell growth and several transformed properties were investigated.

Results: The stable expression of Pin1-specific small interfering RNA constructs in PC3 and LNCaPce lls significantly reduced cellular proliferation, colony formation, migration, and invasion but strongly enhanced the apoptotic response induced by serum depletion or treatment with anticancer agents. Furthermore, Pin1depletion [sic] significantly suppressed tumorigenic potential in athymic mice, resulting in the inhibition of both tumor growth and angiogeneisis.

Conclusions: These results strongly suggest that Pin1plays [sic] an important role not only in tumorigenesis but also in the maintenance of the transformed phenotype in prostate cancer cells.

Anmerkungen

Although identical, nothing has been marked as a citation.

Though "RYO et al." is named as some kind of reference, the article, where this passage comes from, is not to be found in Rlm's list of references.

Sichter
(Graf Isolan), SleepyHollow02


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