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SleepyHollow02
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Untersuchte Arbeit:
Seite: 16, Zeilen: 1 ff. (entire page)
Quelle: SABiosciences Androgen Signaling 2009
Seite(n): online, Zeilen: -
The AR corepressor HBO1 is a member of MYST protein family that is characterized by a homologous zinc finger and carries an acetyltransferase domain. Although AR is normally thought to function as a homodimer, it has been found to heterodimerize with other nuclear receptors including the ER( Estrogen Receptor), GR ( Glucocorticoid Receptor) and TR4(Testicular Orphan Receptor 4) and in each case result in a decrease in AR transcriptional activity. In addition to the transcriptional or genomic mode of action by steroids, androgens, can also exert rapid, nongenomic effect. Nongenomic steroid activity typically involves the rapid induction of conventional second messenger signal transduction cascades. Nongenomic action of androgens can occur through multiple receptors. Androgens also stimulate an elevation in intracellular Ca2+ through GPCR(G-Protein Coupled Receptor) by activating an influx through nonvoltage-gated Ca2+ channels.The elevation of intracellular calcium activates signal transduction cascades, including PKA(Protein Kinase-A),PKC(Protein Kinase-C), and MAPKs( Mitogen Activated Protein Kinase), that can modulate the activity of the ARs and other transcription factors.

AR also interacts with intracellular tyrosine Kinase c-Src, triggering c-Src activation. One of the targets of c-Src is the adapter protein SHR [(SH2 Containing Protein), an upstream regulator of the MAPK pathway (18).]


18) Hao Yun Wong, Jan A. Burghoorn, Marije van Leeuwen, Petra E. De Ruiter, Esther Schippers, Leen J. Blok, Ka Wan LI, Henk L. Dekker, Luitzen De Jong, Jan Trapman, J. Anton Grotegoedand Albert O. Btinkmann. Phosphorylation of androgen receptor isoforms.Biochem J. 2004 Oct 15;383(Pt 2):267-76

The AR corepressor HBO1 is a member of the MYST protein family that is characterized by a homologous zinc finger and carries an acetyltransferase domain. Although AR is normally thought to function as a homodimer, it has been found to heterodimerize with other nuclear receptors including the ER (Estrogen Receptor), GR (Glucocorticoid Receptor) and TR4 (Testicular Orphan Receptor-4) and in each case result in a decrease in AR transcriptional activity.

In addition to the transcriptional or genomic mode of action by steroids, androgens, can also exert rapid, nongenomic effects. Nongenomic steroid activity typically involves the rapid induction of conventional second messenger signal transduction cascades. Nongenomic action of androgens can occur through multiple receptors. [...] Androgens also stimulate an elevation in intracellular Ca2+ through a GPCR (G-Protein Coupled Receptor) by activating an influx through nonvoltage-gated Ca2+ channels. The elevation of intracellular calcium activates signal transduction cascades, including PKA (Protein Kinase-A), PKC (Protein Kinase-C), and MAPKs (Mitogen-Activated Protein Kinase), that can modulate the activity of the ARs and other transcription factors. AR also interacts with the intracellular tyrosine kinase c-Src, triggering c-Src activation. One of the targets of c-Src is the adapter protein SHC (SH2 Containing Protein), an upstream regulator of the MAPK pathway.

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Sichter
(SleepyHollow02), Hindemith

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