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Typus
Verschleierung
Bearbeiter
SleepyHollow02
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 17, Zeilen: 1 ff. (entire page)
Quelle: SABiosciences Androgen Signaling 2009
Seite(n): online, Zeilen: -
[One of the targets of c-Src is the adapter protein SHR] (SH2 Containing Protein), an upstream regulator of the MAPK pathway (18). AR phosphorylation by ERK2 is associated with enhanced AR transcriptional activity and an increased ability to recruit the coactivator ARA 70.The SRC family of transcriptional coactivators: SRC1, SRC3, and TIF2( Transcription Intermedary Factor -2) are targets of MAPK phosphoryation that result s in an increased ability of these coactivators to recruit additional coactivators complexes to the DNA-bound receptor. The non genomic rapid stimulation of the second messenger cascades by androgens may ultimately exert biological effects through modulation of the transcriptional activity of AR or other transcription factors. Such modulation may occur through direct phosphorylation of activators or their coregulators.

18) Hao Yun Wong, Jan A. Burghoorn, Marije van Leeuwen, Petra E. De Ruiter, Esther Schippers, Leen J. Blok, Ka Wan LI, Henk L. Dekker, Luitzen De Jong, Jan Trapman, J. Anton Grotegoedand Albert O. Btinkmann. Phosphorylation of androgen receptor isoforms.Biochem J. 2004 Oct 15;383(Pt 2):267-76

One of the targets of c-Src is the adapter protein SHC (SH2 Containing Protein), an upstream regulator of the MAPK pathway. [...] AR phosphorylation by ERK2 is associated with enhanced AR transcriptional activity and an increased ability to recruit the coactivator ARA70. The SRC family of transcriptional coactivators: SRC1, SRC3, and TIF2 (Transcription Intermediary Factor-2) are targets of MAPK phosphorylation that results in an increased ability of these coactivators to recruit additional coactivator complexes to the DNA-bound receptor. The nongenomic, rapid stimulation of second messenger cascades by androgens may ultimately exert biological effects through modulation of the transcriptional activity of AR or other transcription factors. Such modulation may occur through direct phosphorylation of transcriptional activators or their coregulators (Ref.1).

1. Heinlein CA, Chang C The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol. 2002 Oct;16(10):2181-7.

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Sichter
(SleepyHollow02), Hindemith

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