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Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 21, Zeilen: 1-8
Quelle: Narayanan et al 2010
Seite(n): 842, Zeilen: 15-19
SNARE-1 inhibits the androgen-sensitive growth of LNCaP cells and tumor xenografts. Quantitative subcellular localization studies suggest that SNARE-1 inhibits nuclear translocation of AR, but also facilitates export of nuclear AR that has been translocated by an agonist. Mechanistic studies indicate that SNARE-1 rapidly phosphorylates p38 mitogen-activated protein kinase (MAPK) and Ser650 of the AR facilitating the nuclear export of AR. Additionally, SNARE-1 was found to promote ubiquitination of AR in LNCaP cells (30).

30) Ramesh Narayanan, Muralimohan Yepuru, Adam T. Szafran, Maria Szwarc, Casey E. Bohl, Natalie L. Young, Duane D. Miller, Michael A. Mancini, and James T. Dalton. Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer. Cancer Research 2010 Jan 15;70(2):842-51. Epub 2010 Jan 12.

SNARE-1 inhibits the androgen-sensitive growth of LNCaP cells and tumor xenografts. Quantitative subcellular localization studies suggest that SNARE-1 inhibits nuclear translocation of AR, but also facilitates export of nuclear AR that has been translocated by an agonist. Mechanistic studies indicate that SNARE-1 rapidly phosphorylates p38 mitogen-activated protein kinase (MAPK) and Ser650 of the AR. Additionally, SNARE-1 was found to promote ubiquitination of AR in LNCaP cells.
Anmerkungen

Taken verbatim from the original source, continued from previous page. Alhough the authors are mentioned here, it has not been marked that the take-over has been word by word.

Sichter
(Graf Isolan), SleepyHollow02

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