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Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes
Untersuchte Arbeit:
Seite: 30, Zeilen: 1-6
Quelle: Bao et al 2004
Seite(n): 1227, 1731, Zeilen: 1227: r.col: 29 ff.  ; 1731: l.col: 6 ff.
Pin1 is normally expressed at very low levels in most normal tissues, although significant levels of Pin1 are often found in cell types that normally undergo active cell division. Pin1 is overexpressed in some human malignancies and that its expression closely correlates with the level of cyclin D1 in human breast cancer (54).

54) Wulf, G. M., Ryo, A., Wulf, G. G., Lee, S. W., Niu, T., and Lu, K. P. Pin1 is overexpressed in breast cancer and potentiates the transcriptional activity of phosphorylatedc-Jun towards the cyclin D1 gene. EMBO J., 20: 3459–3472, 2001.

Recently, it has been reported that Pin1 is overexpressed in human breast cancer cell lines and breast cancer tissues, and its expression closely correlates with the level of cyclin D1 in tumors.15

[page 1731]

These results indicate that Pin1 is normally expressed at very low levels in most normal tissues, although significant levels of Pin1 are often found in cell types that normally undergo active cell division.


15. Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Lu KP: Pin1 is overexpressed in breast cancer and potentiates the transcriptional activity of phosphorylated c-Jun towards the cyclin D1 gene. EMBO J 2001, 20:3459–3472

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Sichter
(Hindemith), SleepyHollow02